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The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)
is still not clear. In this dissertation, we hypothesize that DIM works through estrogen receptor (ER) signaling to inhibit prostate cancer. We focus on DIM's interaction with ER, as well as its effects on preventing advanced prostate cancer and weight gain...
Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
(University of Missouri--Columbia, 2018)
Over the last few decades, antibodies have become the mainstay of cancer diagnosis and therapeutics. In traditional radioimmunotherapy (RIT), tumor targeting antibodies are directly conjugated with radioisotopes and depending ...