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The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
affinity was not affected significantly by the size of the dioxy ring. The modification of the strained tetrahydroisoquinoline ring with a freely rotating amine chain maintained the sigma1 affinity unchanged, while decreasing the sigma2 binding affinity...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
Supramolecular, self-assembled nanocapsules have shown the capability to encapsulate organic guests. Since most of the work was done previously in the solid state, the novelty of this research was its focus on probing ...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ultra violet resonance Raman (UVRR) is a powerful spectroscopic technique for determining the secondary structural content of proteins in solution. ...
Anion and solvent influences on the self-assembly of copper(I) coordination solids
(University of Missouri--Columbia, 2005)
The investigation of solvent and anion influences on the self-assembly of copper(I) coordination solids are presented. As these extended solids vary in structural design as reactions conditions are varied, both those ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of ...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
and functionalities of such nanomaterials. This dissertation reports strategies for metal colloidal nanocrystal synthesis in sustainable media and aims to build a foundation for understanding how to tailor eco-friendly IL and DES fluids to control the growth of metal...
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroli ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
dipole alignment with computations and experiments. The last chapter of the dissertation is concerned with an entirely different topic, namely the challenges of preparing college students for science communication. In Chapter 7, the design and development...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following ...
Synthesis, characterization, and reactivity of actinide complexes bearing An-E bonds (An = Th, U; E = P, As)
(University of Missouri--Columbia, 2021)
-metal phosphinidiide complexes of the form {(C5Me5)2Th[[mu]2-P(Mes)][[mu]2-P(H)Mes]M(L)n}2 (L = THF, Et2O), where computational (DFT) analysis and 31P NMR spectroscopy suggests significant Th-P multiple bond character. Reaction of (C5Me5)2Th[P(H)Mes]2 with CuMes in a 2...
Broadband rotational spectroscopy in Laval flows: applications in astrochemistry and dynamics
(University of Missouri--Columbia, 2022)
This dissertation presents the successful implementation of a Chirped pulse Uniform Flow (CPUF) apparatus capable of conducting experiments at low temperatures to examine photodissociation/reaction dynamics and kinetics studies relevant...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
and error checking based upon self-complementary hydrogen bonding has resulted in the formation of nanometer-sized spheroidal structures. he following dissertation comprises three closely related sets of studies, the design and construction of large...
Investigation and modeling of carbon dioxide adsorption within porous materials
(University of Missouri--Columbia, 2023)
Mathematics has long been my special interest. With that in mind, if I make any operations which are unobvious to the reader, I deeply apologize. I often forget that, even within the STEM fields, not everyone enjoys spending ...
Diels-alder reactions of a cyclopentadienone derivative
(University of Missouri--Columbia, 2007)
An ester derivative of cyclopentadienone, a very reactive species, was generated from methyl-2-bromo-3-oxocyclopent-1-enecarboxylate (96) which dimerized instantaneously and decarbonylated to generate an indanone (97). ...
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)
) and inhibiting the signaling pathways that maintain the pluripotent phenotype (FGF2 and ACTIVIN A). The central theme of my dissertation has been to use these stem cellderived TB to model the early placental structure known as the primitive syncytium. My research...
Self-assembly of functional metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2022)
C-alkylpyrogallol[4]arenes (PgCns, where n is the represents pendant alkyl chain lengths), bowl-shaped macrocycles, upon deprotonation, can self-assemble with metal ions into dimeric (M8L2) and hexameric (M24L6) metal-organic ...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
Research Reactor (MURR) has demonstrated the therapeutic analogue, 77As, can be produced routinely from 76Ge targets, but the diagnostic analogue, 72As, can be made available from the decay of 72Se in the form of a 72Se/72As generator. This research...
2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
The synthesis of chiral ligands to tune the reactivity and stereoselectivity of many catalytic asymmetric reactions has been given considerable attention in synthetic organic chemistry over the past decade. This report ...
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "The field of chemical reaction dynamics is based upon understanding the details of elementary chemical reactions. It seeks to answer fundamental ...
Probing synthesis of L-ascorbic acid in Arabidopsis thaliana genotypes
(University of Missouri--Columbia, 2021)
L-Ascorbic acid (L-AsA), also known as vitamin C, is a crucial vitamin for both plants and animals due to its antioxidant properties and abilities to scavenge harmful reactive oxygen species (ROS). However, some animals ...