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Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)
Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ...
Investigating the deleterious role of B lymphocytes during brucella infection
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a disease known for inducing chronic, often life-long, infections. While it is clear the host immune response fails to clear ...
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)
The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ...
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)
-based methods of Tat-POSH-inhibitor delivery. The work presented in this dissertation aims to establish POSH as a novel therapeutic target for treatment of acute and chronic B cell leukemias....
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)
dissertation work has developed deeply towards identifying and characterizing enzymatic inferences grounded firmly in conserved protein structure with the specific applications in anti-viral drug resistance and enzyme kinetics. Rather than focusing on a single...