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Development of a flexible image-based approach for studying signal transduction in isolated arterioles
(University of Missouri--Columbia, 2007)
Myogenic constriction in arterioles occurs when membrane tension leads to smooth muscle depolarization and voltage-gated calcium channel activation. A barrier to understanding the exact signaling events is the limited ...
A ratiometric fluorometer for reduced sensitivity against solvent artifacts
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] When measuring fluorescence emission intensity, both the dye concentration and the optical absorption properties of the solvent influence the measured intensity. As a consequence...
Accurate DNA microsatellite and microRNA detection with a biological nanopore
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Nanopore-based detection has been used in many genetic, epigenetic, proteomic, and bio-mechanism studies. In this report, we introduced two designed strategies...
Targeted therapeutics for non small cell lung carcinoma
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "Lung carcinoma, also known as lung cancer, is a malignant tumor of lungs characterized by uncontrolled call growth in lung tissue. Tobacco smoking is the reason for nearly 85...
Modeling the impact of polystyrene microparticles on toxicity of phenol to Artemia
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The increasing use and availability of micro and nanoparticles for use in science, technology and daily consumer products has led to unique challenges related to understanding...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Imaging structurual and mechanical properties in cardiovascular tissue using optical polarization tractography
(University of Missouri--Columbia, 2022)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the US. Every 36 seconds, one person dies from CVD [1]. Structural deficiencies and secondary changes induced by either abnormal functioning ...
Engineering target nanomaterials for stable and efficient delivery of siRNA
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Lung cancer has the highest cancer-related mortality rate in the United States. The most common form of lung cancer is non-small cell lung cancer (NSCLC) with 80...
Flourescent molecular rotors as mechanosensors in biofluids
(University of Missouri--Columbia, 2005)
Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. ...
Development of high-resolution optical tomography with a larger-size projection acquisition
(University of Missouri--Columbia, 2007)
In the industrial countries, the mortality from arteriosclerosis and cardiovascular diseases has been decreased, but they remain the most common circulatory disease. Recently, new tissue engineering technologies such as ...