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Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
(University of Missouri--Columbia, 2018)
acid transporter, in restricted placentae.These changes in placentae from dams fed a nutrient restricted diet suggestsome compensation to ensure adequate nutrients are available to the fetus forproper development.I also examined the effects MUN...
Friends in high places : ecology of mycorrhizal associations in alpine plant communities
(University of Missouri--Columbia, 2010)
Mutualisms are ubiquitous in nature, yet these interactions often vary in strength and persistence. This variation raises the questions of what determines whether mutualisms persist or vanish, and how does variation in the ...
Cellular behaviors regulating tangential migration of facial branchiomotor neurons in the zebrafish embryo
(University of Missouri--Columbia, 2009)
Development of the nervous system is characterized by intricate processes like neuronal migration, axon outgrowth and guidance and synaptic connections to their targets. These processes involve navigation of the migrating ...
Generating temperature sensitive inteins for studying gene functions
(University of Missouri--Columbia, 2008)
Reversible and easy to use, temperature-sensitive (TS) mutations, are powerful tools to study the functions of all genes, including essential and pleiotropic ones. However, the rarity of TS alleles and the difficulty of ...
Characterizing a model of early human placenta
(University of Missouri--Columbia, 2020)
been learned about the structures of the embryo formed during this time, but any experimentation to determine function is impossible. This is not only due to ethical restrictions but also due to the fact that women are unaware of when implantation...
Novel approach to assessment of efficacy of platelet inhibition by clopidogrel and aspirin in healthy dogs
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Introduction: Antiplatelet therapy, including clopidogrel and aspirin, is used to decrease the risk of thromboembolism in dogs. However, efficacy of therapy...
The secret lives of African forest elephants: using genetics, networks, and telemetry to understand sociality
(University of Missouri--Columbia, 2012)
through observations in 2006, 2008, and 2010. Social networks revealed evidence of kin-based fission-fusion sociality. Although forest elephant females associate in fission-fusion patterns, they frequently separate from them, and when preferred...
Elucidation of the genetic control of carbohydrate partitioning in Zea mays
(University of Missouri--Columbia, 2019)
Carbohydrate partitioning, the process of transporting carbohydrates from sites of synthesis in hotosynthetic tissue to developing sink tissues, is crucial for the growth, development, and yield in plants and crops. ...
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase enzymes, which...
Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons
(University of Missouri--Columbia, 2019)
Ionic currents drive cellular function within all living cells to perform highly specific tasks. For excitable cells, such as muscle and neurons, voltage-gated ion channels have finely tuned kinetics that allow the ...
Establishing a foundation for large DNA transfer to artificial minichromosomes and B insert platforms in maize
(University of Missouri--Columbia, 2019)
In plants, conventional genetic engineering methods limit the number of available traits that could potentially improve the quality of agriculture. Agrobacterium-mediated transformation and biolistic bombardment are tools ...
Conservation and ecology of breeding landbirds in a riparian restoration context
(University of Missouri--Columbia, 2006)
While $14 to $15 billion have been invested in 37,000+ river and stream restoration projects in North America since 1990, only 10% are monitored for biological function. My work examines factors that affect landbird ...
Dissecting the genetic basis of carbohydrate partitioning in maize and sugarcane
(University of Missouri--Columbia, 2022)
Carbohydrate partitioning, the process by which carbohydrates synthesized in the photosynthetic source tissues (mature leaves) are mobilized to non-photosynthetic (sink) tissues, such as roots, seeds, and developing organs ...
Intervertebral discs : metabolic responses to load, injury, and pro-inflammatory stimulation
(University of Missouri--Columbia, 2020)
Introduction: Intervertebral disc (IVD) degeneration is a significant cause of back pain and disability. Factors such as trauma and magnitude and frequency of loading are associated with IVD degeneration. However, the ...
Neuroscience tools in novel contexts: developing thermogenetics in Drosophila and decoding autonomic activity in mouse major pelvic ganglion
(University of Missouri--Columbia, 2022)
Animal research models provide the opportunity to decode neural activity via the ability to precisely stimulate and record neural events associated with quantifiable circuit and behavioral outputs (Bernstein et al., 2012; ...
The impacts of partner abundance on benefits from facultative pollination mutualism
(University of Missouri--Columbia, 2010)
Partner abundance affects costs and benefits in obligate mutualisms, but its role in facultative partnerships is less clear. I investigated this topic in a small alpine pollination web in the Colorado Rocky Mountains ...
Mating systems in Nicotiana longiflora and N. Plumbaginifolia : the effect of interspecific interactions
(University of Missouri--Columbia, 2008)
The research presented here was focused on the effects of interactions between Nicotiana longiflora and N. plumbaginifolia on their mating systems. First, I conducted a series of observations and pollination experiments ...
Phylogenomics of orchids and their mycorrhizal fungi : trees, diversity, and the pursuit of symbiosis
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Phylogenetic trees show us how organisms are related and provide frameworks for studying and testing evolutionary hypotheses. To better understand the evolution of orchids...
Genome-wide exploration of direct GBX2 target genes and their contributions to mouse development
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The cells that comprise the vertebrate nervous system require molecular cues to determine their cellular position, identity and their ability to make appropriate connections...
Developmental programming by xenoestrogens
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Xenoestrogens (XE) are chemicals in the environment that mimic the body's natural steroidal estrogens. Developmental exposure to XE may interfere with normal hormonal signaling...