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Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
(University of Missouri--Columbia, 2018)
to the CDC, in 2011 more than 35% of the U.S. population was obese, with a financial burden of US $147 billion annually. Though improper diet, lack of exercise and socioeconomic status areassociated with these adult diseases, inadequate maternal nutrition...
The secret lives of African forest elephants: using genetics, networks, and telemetry to understand sociality
(University of Missouri--Columbia, 2012)
Knowledge of social structure is important to understanding the overall evolution and behavioral ecology of a species as it ultimately influences spatial patterns and gene flow. This dissertation focuses on the social structure of African forest...
Friends in high places : ecology of mycorrhizal associations in alpine plant communities
(University of Missouri--Columbia, 2010)
Mutualisms are ubiquitous in nature, yet these interactions often vary in strength and persistence. This variation raises the questions of what determines whether mutualisms persist or vanish, and how does variation in the ...
Flipping the switch : regulation of proliferation and differentiation in adult muscle stem cells
(University of Missouri--Columbia, 2011)
Adult muscle stem cells or satellite cells are the committed somatic stem cells responsible for maintenance and regeneration of adult skeletal muscle tissue. Skeletal muscle is capable of multiple rounds of complete ...
Characterizing a model of early human placenta
(University of Missouri--Columbia, 2020)
been learned about the structures of the embryo formed during this time, but any experimentation to determine function is impossible. This is not only due to ethical restrictions but also due to the fact that women are unaware of when implantation...
Developmental programming by xenoestrogens
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Xenoestrogens (XE) are chemicals in the environment that mimic the body's natural steroidal estrogens. Developmental exposure to XE may interfere with normal hormonal signaling...
Genome-wide exploration of direct GBX2 target genes and their contributions to mouse development
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The cells that comprise the vertebrate nervous system require molecular cues to determine their cellular position, identity and their ability to make appropriate connections...
Neuroscience tools in novel contexts: developing thermogenetics in Drosophila and decoding autonomic activity in mouse major pelvic ganglion
(University of Missouri--Columbia, 2022)
Animal research models provide the opportunity to decode neural activity via the ability to precisely stimulate and record neural events associated with quantifiable circuit and behavioral outputs (Bernstein et al., 2012; ...
Mapping nif genes of Rhodobacter capsulatus, and characterization of a mutant with a pleiotropic defect in nitrogen metabolism
(University of Missouri--Columbia, 1988)
Mutations affecting the ability of the photosynthetic bacterium Rhodobacter capsulatus to fix nitrogen (Nif- ) have previously been mapped into six linkage groups (I-VI) by transduction with gene transfer agent (GTA). ...
Novel approach to assessment of efficacy of platelet inhibition by clopidogrel and aspirin in healthy dogs
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Introduction: Antiplatelet therapy, including clopidogrel and aspirin, is used to decrease the risk of thromboembolism in dogs. However, efficacy of therapy...
Elucidation of the genetic control of carbohydrate partitioning in Zea mays
(University of Missouri--Columbia, 2019)
Carbohydrate partitioning, the process of transporting carbohydrates from sites of synthesis in hotosynthetic tissue to developing sink tissues, is crucial for the growth, development, and yield in plants and crops. ...
Establishing a foundation for large DNA transfer to artificial minichromosomes and B insert platforms in maize
(University of Missouri--Columbia, 2019)
In plants, conventional genetic engineering methods limit the number of available traits that could potentially improve the quality of agriculture. Agrobacterium-mediated transformation and biolistic bombardment are tools ...
Phylogenomics of orchids and their mycorrhizal fungi : trees, diversity, and the pursuit of symbiosis
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Phylogenetic trees show us how organisms are related and provide frameworks for studying and testing evolutionary hypotheses. To better understand the evolution of orchids...
Intervertebral discs : metabolic responses to load, injury, and pro-inflammatory stimulation
(University of Missouri--Columbia, 2020)
Introduction: Intervertebral disc (IVD) degeneration is a significant cause of back pain and disability. Factors such as trauma and magnitude and frequency of loading are associated with IVD degeneration. However, the ...
Periconceptional, gestational, and lactational exposure to unconventional oil and gas chemical mixture alters energy expenditure in adult female mice
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unconventional oil and gas (UOG) processes involves injection of pressurized water, chemicals, and suspended solids thousands of feet under the surface to release natural gas...
Dissecting the genetic basis of carbohydrate partitioning in maize and sugarcane
(University of Missouri--Columbia, 2022)
growth, development, and yield. Various physiological, biochemical, and anatomical studies have addressed this process, but the genetic control of carbohydrate partitioning is still not well understood. The main purpose of this dissertation...
Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons
(University of Missouri--Columbia, 2019)
Ionic currents drive cellular function within all living cells to perform highly specific tasks. For excitable cells, such as muscle and neurons, voltage-gated ion channels have finely tuned kinetics that allow the ...
Genetic diversity and distribution of the ringed salamander (ambystoma annulatum) across multiple spatial scales
(University of Missouri--Columbia, 2018)
Species distributions are governed by a complex suite of abiotic and biotic interactions that govern movement of individuals and are variable through time and space. These dynamic processes, such as shifts in temperature ...
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase enzymes, which...
Genetic and hormonal regulation of meristem initiation and maintenance pathways during maize vegetative and reproductive development
(University of Missouri--Columbia, 2021)
Plant development is driven by pools of undifferentiated stem cells called meristems. Meristems have two functions, to divide producing cells that will replenish the stem-cell niche, and cells that will differentiate into ...