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Regulation of early trophoblast differentiation and development
(University of Missouri--Columbia, 2010)
have used immunohistochemical staining for specific pluripotent markers Oct-4 and SSEA 3 and differentiation marker SSEA 1 to assess the effect of low oxygen tension on the development of hES cells. We observed that low O[subscript 2] tension prevents...
New perspective on the role of conceptus estrogens in conceptus development, maternal recognition, and the establishment of pregnancy in pigs.
(University of Missouri--Columbia, 2018)
The proposed signal for maternal recognition of pregnancy in pigs is estrogen, produced by the elongating conceptus. To understand the role of estrogen in porcine conceptus elongation and pregnancy establishment, a loss ...
Development and analysis of a FOXA2 conditional overexpression mouse model
(University of Missouri--Columbia, 2018)
The uterus is essential for mammalian reproduction as it provides environment for conceptus implantation and subsequent development. Endometrial glands synthesize and secrete or transport substances critical for conceptus ...
Paternal developmental exposure to endometriosis causes negative transgenerational impacts on male fertility
(University of Missouri--Columbia, 2018)
(IBFC) with biomarkers of histone H3 methylation (H3K9me3; retention is associated with reduced sperm quality in rodents) and sperm surface glycosylation (lectin Lens culinaris agglutinin/LCA has high affinity for defective sperm surface) were used...
Structural variation at the KIT locus is responsible for the piebald phenotype in Hereford and Simmental cattle
(University of Missouri--Columbia, 2014)
The Spotted locus is responsible for white spotting (piebald) coat color phenotypes in cattle. Since the Hereford breed is fixed for this phenotype, we postulate that a selective sweep occurred during breed formation to ...
Biology of uterine glands : impact on reproductive function
(University of Missouri--Columbia, 2018)
environment; (2) leukemia inhibitory factor (LIF), and other gland-derived products, are not present within the uterine fluid during the periimplantation period; (3) FOXA2 regulates uterine expression of Lif; (4) LIF-repletion is sufficient for pregnancy...
Biology of uterine glands : impact on reproductive function
(University of Missouri--Columbia, 2018)
environment; (2) leukemia inhibitory factor (LIF), and other gland-derived products, are not present within the uterine fluid during the periimplantation period; (3) FOXA2 regulates uterine expression of Lif; (4) LIF-repletion is sufficient for pregnancy...
Uterine regulation of preimplantation embryo development in fertility-classified heifers
(University of Missouri--Columbia, 2018)
, serial embryo transfer (3-4 rounds) was used to classify heifers based on pregnancy success on day 28 as high fertile (HF; 100%), subfertile (SF; 25%), or infertile (IF; 0%). Next, a series of experiments were conducted using the fertility...
Extracellular vesicles : novel mediators of conceptus-maternal interactions in sheep
(University of Missouri--Columbia, 2018)
indicating a role in intercellular communication during the establishment of pregnancy; (4) uterine EV content increases more than five-fold from day 10 to 14 of the estrous cycle; (5) the endometrial epithelia produce EVs with multivesicular endosomes...
Genetics in practice : applications of quantitative genetics to environment and educational pursuits
(University of Missouri--Columbia, 2018)
"The ability to elucidate quantitative trait architecture and introduce potentially beneficial traits makes introgression a useful tool. Unfortunately, due to the nature of inheritance there are certainly limitations to ...