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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
The research presented in this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. ...
Bayesian Change Point Analysis of Copy Number Variants Using Human Next Generation Sequencing Data
Read count analysis is the principal strategy implemented in detection of copy number variants using human next generation sequencing (NGS) data. Read count data from NGS has been demonstrated to follow non homogeneous ...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
Expansion of high-throughput sequencing technology has increased our understanding in the importance of pervasive transcription and the resulting indispensable molecules, noncoding RNAs (ncRNAs). A significant effort has ...