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Regulation of early trophoblast differentiation and development
(University of Missouri--Columbia, 2010)
have used immunohistochemical staining for specific pluripotent markers Oct-4 and SSEA 3 and differentiation marker SSEA 1 to assess the effect of low oxygen tension on the development of hES cells. We observed that low O[subscript 2] tension prevents...
Efforts to identify large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses
(University of Missouri--Columbia, 2021)
Large offspring syndrome (LOS) is a fetal overgrowth condition observed in some bovine offspring produced in vitro. The main phenotypes of LOS is large body size due to overgrowth during development which can result in ...
Biology of uterine glands : impact on reproductive function
(University of Missouri--Columbia, 2018)
environment; (2) leukemia inhibitory factor (LIF), and other gland-derived products, are not present within the uterine fluid during the periimplantation period; (3) FOXA2 regulates uterine expression of Lif; (4) LIF-repletion is sufficient for pregnancy...
Biology of uterine glands : impact on reproductive function
(University of Missouri--Columbia, 2018)
environment; (2) leukemia inhibitory factor (LIF), and other gland-derived products, are not present within the uterine fluid during the periimplantation period; (3) FOXA2 regulates uterine expression of Lif; (4) LIF-repletion is sufficient for pregnancy...
Development and analysis of a FOXA2 conditional overexpression mouse model
(University of Missouri--Columbia, 2018)
The uterus is essential for mammalian reproduction as it provides environment for conceptus implantation and subsequent development. Endometrial glands synthesize and secrete or transport substances critical for conceptus ...
New perspective on the role of conceptus estrogens in conceptus development, maternal recognition, and the establishment of pregnancy in pigs.
(University of Missouri--Columbia, 2018)
The proposed signal for maternal recognition of pregnancy in pigs is estrogen, produced by the elongating conceptus. To understand the role of estrogen in porcine conceptus elongation and pregnancy establishment, a loss ...
Studies of ruminant digestion, ecology, and evolution
(University of Missouri--Columbia, 2008)
theory) that predicted feed intake of wild and domestic ruminants precisely (generally R[superscript 2] [greater than] 0.9, root mean square prediction error [less than] 1.4 kg d-1). We then used this mechanistic model, along with allometric equations...
Molecular regulation of fetal brain development in pigs
(University of Missouri--Columbia, 2021)
molecular processes. A comparative analysis (Chapter 4) compared the gene expression patterns in the fetal brain and placenta between pigs and mice. The analysis identified 112 genes that were expressed (mean FPKM > 10) in the fetal brain of both species...
Regulation of fetal brain development in short versus long lived mice
(University of Missouri--Columbia, 2022)
Cav-1. Lastly, in the third study (Chapter 4), experiments were performed to test if reduced lifespan in mice due to murine leukemia virus induced cancer influences fetal brain development. In this experiment, gene expression pattern of fetal brain...
Extracellular vesicles : novel mediators of conceptus-maternal interactions in sheep
(University of Missouri--Columbia, 2018)
indicating a role in intercellular communication during the establishment of pregnancy; (4) uterine EV content increases more than five-fold from day 10 to 14 of the estrous cycle; (5) the endometrial epithelia produce EVs with multivesicular endosomes...
Cotton seed and cotton-seed products as feeds for live stock
(University of Missouri--Columbia, 1916)
The purpose of this work was to get together the results of the different experiments with cotton seed and cotton seed products in order that comparisons might be made of the feeding values of the different products with ...
Glutamine metabolism and interactions with mechanistic target of rapamycin complex 1 in porcine preimplantation embryos
(University of Missouri--Columbia, 2021)
The ability to culture embryos has created opportunities for animal agriculture, including the refined selection of superior genetics, and for the medical field, allowing couples experiencing infertility to have biological ...
Uterine regulation of preimplantation embryo development in fertility-classified heifers
(University of Missouri--Columbia, 2018)
, serial embryo transfer (3-4 rounds) was used to classify heifers based on pregnancy success on day 28 as high fertile (HF; 100%), subfertile (SF; 25%), or infertile (IF; 0%). Next, a series of experiments were conducted using the fertility...
Improving viability of immunodeficient RAG2-/- pigs by non-specific porcine antibody administration
(University of Missouri--Columbia, 2020)
(SQ) (n=3), or intraperitoneal (IP) (n=4) route to evaluate which presented the best uptake. Average lifespan for the IV, SQ, and IP pigs was 60 days [plus or minus] 5.72, 56.3 [plus or minus] 14.97 days, and 102.5 [plus or minus] 6.1 days...
Digestible lysine and threonine requirements of male turkeys and their effects on performance of male turkeys fed practical diets to market age
(University of Missouri--Columbia, 2008)
Seven experiments were conducted to determine the minimum requirements of digestible lysine (dLys) and digestible threonine (dThr) from 1 to 21 weeks of age for male turkeys. Requirement values were similar to NRC (1994) ...
Ablation of conceptus PTGS2 provides a new understanding of early pregnancy events in the pig
(University of Missouri--Columbia, 2019)
Pig conceptuses produce and secrete estrogens (E[2]), interleukin 1 beta 2 (IL1B2), and prostaglandins (PGs) during the period of rapid trophoblast elongation and establishment of pregnancy. Previous studies established ...
Extracellular vesicles, lipids, and lipoproteins in early pregnant sheep
(University of Missouri--Columbia, 2021)
, characterize, and/or determine the roles of: (1) extracellular vesicles (EVs); (2) lipids and metabolites; (3) prostaglandins (PGs); and (4) apolipoproteins present within the ULF of ewes during early gestation. Collectively, the present studies established...
Involvement of mitochondrial transcription factor A (TFAM) in porcine gametogenesis and preimplantation embryo development
(University of Missouri--Columbia, 2007)
Mitochondrial Transcription Factor A (TFAM) is responsible for maintenance and transcriptional control of mitochondrial DNA (mtDNA). TFAM knockout is embryolethal. We have studied the expression and distribution of TFAM ...
Generation of a reference genome to investigate population fitness and transitional cell carcinoma occurrence in the fishing cat (Prionailurus viverrinus)
(University of Missouri--Columbia, 2022)
Many species are vulnerable or on the verge of extinction as a result of increased habitat degradation and fragmentation. Conservation genetics has attempted to apply an understanding of species genetics to reduce the risk ...
Genetics in practice : applications of quantitative genetics to environment and educational pursuits
(University of Missouri--Columbia, 2018)
"The ability to elucidate quantitative trait architecture and introduce potentially beneficial traits makes introgression a useful tool. Unfortunately, due to the nature of inheritance there are certainly limitations to ...