Conjugated polymers have found a wide range of electronic applications in last few decades due to their superior combination of optoelectronic, mechanical properties, and solution processability. In the past few years, ...

We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ...

Pentablock (PB) copolymers have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as ...

Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ...

The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ...

The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...

The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...

Biomacromolecules, mainly nucleic acids and proteins, are involved in every cellular process and therefore their aberrant level or function is linked with most of the diseases. Controlling these macromolecules using light ...

HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection due to anatomical and physiological ...

The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce ...

For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ...

Random triblock copolymers (RTB) were successfully synthesized by ring opening copolymerization method. RTB copolymers are composed of FDA approved materials such as polyethylene glycol (PEG), glycolide (GA), lactide ...

, gatifloxacin. A second dimension involved screening in the presence and absence of cefoxitin to identify synergistic agents. Several drugs exhibited synergy with cefoxitin against MRSA that includes floxuridine, gemcitabine, novobiocin, rifaximin and 4...

The objective of this dissertation is to develop a protein-based siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...

Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic intracellular drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and ...

) and in vitro cytotoxicity studies in corneal, conjunctival and retinal cell-lines. Newly synthesized polymers were purified and characterized for their structure and molecular weights by H¹-NMR and GPC, respectively. The CMCs were found to be 0.13, 4.48 and 6...