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Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
Polycyclic aromatic hydrocarbons (PAHs) are interesting discotic liquid crystalline materials. Their often planar or near-planar geometry and extended π-delocalization render them appealing π-π stacking building blocks ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)
Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
pentablock polymers based thermosensitive hydrogel by incorporating PLA block in the center of PEG-PCL-PEG. These polymers were characterized by 1H NMR, GPC, and FT-IR. The effect of block composition on the sol-gel transition, crystallinity, and drug release...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Design, synthesis and evaluation of novel intercalator analogs targeting therapeutically important polymerases and folded RNA
(2013)
Polymerases and ribonucleic acids have been found to play major roles in the
causation and progression of several diseases. Targeting such important therapeutic targets
using small molecules can help achieve their specific ...