[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Worldwide, millions of people suffer from symptoms of memory loss and confusion associated with Alzheimer's disease (AD). Mounting evidence suggests ...

the constituent atoms. .. Photodissociation of small molecules has been studied using variety of detection methods, such as, photofragment translational spectroscopy, [4,5] Laser-induced fluorescence (LIF), [6] Doppler-related methods, [7] Rydberg tagging, [8...

spherical multicomponent assemblies via the selfassembly approach. Chapter 2 will describe the formation of very large molecular capsules based upon the self-assembly of six macrocycles called the C-alkylpyrogallol[4]arenes. These molecular capsules are held...

is the study of pyrogallol[4]arene with R-groups R=H and R=phenyl. This macrocycle self-assembles into dimeric and hexameric nanocapsules. Several different structures for the macrocycle and its subunits, their relative energies, and their solvent interactions...

by replacing the left phenylpropyl group of SA4503 with an N-iodoallyl group yielded a sigma1 selective ligand (1h-7, E-IA-DM-PE-PIPZ) that had appropriate lipophilicity for penetrating the blood brain barrier in the CNS. The in vivo studies using...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic substituents was investigated...

novel molecular recognition features of the natural product azinomycin using similar tools (Chapter 4). We characterized novel, reversible chemical reactions of leinamycin (Chapter 3). Amongst these were reversible DNA-alkylation and reversible adduct...

Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ...

Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...

for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...

and remain off (pH=5.5). When stimulated the cell will exocytose the sensor and at pH=7.4, the sensor will fluoresce. The synthesis of pH sensitive fluorescent chemosensors for amines and their properties is described....

Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 and 3 with Re was performed...

and the reaction conditions involved will be discussed. This presentation will be divided into four major sections. The first section covers an in-depth look at those structural variances found among the copper(I) coordination solids synthesized using 4,4...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...

1-Hydroxyphenazine is a secondary metabolite and virulence factor of Pseudomonas aeruginosa. This organism colonizes the airways of the patients of cystic fibrosis and causes progressive destruction of the airways. It is ...

Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pollutants have become more prevalent in the air, water, and ground, necessitating the development of technologies that would help, limit, reverse, ...

The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...

revealed through the use of p-xylene.The third project investigated the interactions between nickel macrocycles and single walled carbon nanotubes. The final project took supramolecular hexamers from the cup-shaped pyrogallol[4]arene and produced large...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ultra violet resonance Raman (UVRR) is a powerful spectroscopic technique for determining the secondary structural content of proteins in solution. ...