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Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Discovery and Delivery of Peptide-Based Immune Checkpoint Inhibitors Targeting Pd-L1 for Cancer Immunotherapy
(2022)
the stability and activity of a linear anti-PD-L1 peptide. The cyclic peptides demonstrated up to a 34-fold improvement in the PD-1/PD-L1 blocking activity and a 4-fold improvement in serum stability. These cyclic peptides prevent apoptosis of human CD3+ T cells...