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Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to facilitate ACV cellular transport. All the prodrugs were screened ...
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)
Proteins are macromolecules involved in a diverse array of functions. Mutations or abnormal levels of proteins are indicated in several diseases. Despite showing early promise, the translation of protein therapeutics ...