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Patient satisfaction and anxiety with informed consent delivered through informational video compared to the traditional physician interview [abstract]
(2010)
Objective: 1. To evaluate patient satisfaction and anxiety towards informed consent with traditional physician interview compared to combination of watching an informational video and patient-specific physician interview. 2. To discover how...
Evaluation of a tranfected HEK293 cell line overexpressing the gc-c receptor [abstract]
(2010-03)
Guanylate cyclase C (GC-C) is typically highly expressed in the brush border of the intestinal epithelium and in human colorectal adenocarcinomas, but is minimally expressed in extraintestinal tissues. Many studies have demonstrated that GC-C is a...
Solitary fibrous tumors of the nasal cavity [abstract]
(2010)
Solitary fibrous tumors are rare mesenchymal-derived neoplasms that are derived from serosal membranes, most commonly from pleural origin. However, a wide variety of extraplural locations have been described. Twenty-two ...
Predictors of tonsillectomy after previous adenoidectomy for upper airway obstruction [abstract]
(2010)
One of the main indications for adenotonsillectomy in children is upper airway obstruction, including obstructive sleep apnea. Previous research has suggested an increased risk for requiring subsequent tonsillectomy when ...
Insulin-mediated increases in arterial baroreflex control of muscle sympathetic nerve activity following meal intake in humans [abstract]
(2010)
Animal studies indicate that insulin enhances arterial baroreflex (ABR) control of sympathetic nerve activity (SNA); however, the extent to which these findings can be extrapolated to humans is unknown. To begin to address ...
Bioinformatic prediction of ultraviolet light mutagenesis sensitive human genes [abstract]
(2010-02)
dimers. If these lesions are not removed by nucleotide excision repair, they often give rise to C to T transition mutations. Based on these observations, a bioinformatics approach was used to predict the vulnerability of every human protein coding gene...
Targeting the guanylate cyclase c receptor with an agonist peptide from enterotoxegenic Y. Enterocolitica [abstract]
(2010-03)
. enterocolitica have evolved ST's which mimic native guanylin/uroguanylin peptides by activating guanylate cyclase C (GC-C), yet possess increased resistance to heat/enzymatic degradation as well as superagonist activity by virtue of a third disulfide bond. We...
RT-PCR on magnetically sorted B-cell subsets from pediatric bone marrow [abstract]
(2010)
has been constructing a cDNA library of normal B-lineage committed lymphoblasts from pediatric bone marrow for comparison. In order to identify unique biomarkers, a relatively quick method for isolating B cell subsets from pediatric bone marrow for RNA...
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract]
(2010-03)
exert influences on bone through the production of endocrine like factors that alter the behavior of bone cells. To test this hypothesis we have cultured MLO-Y4 osteocyte like cells in the presence of conditioned media (CM) from C2C12 differentiated...
Novel inhibitors of Foot and Mouth Disease Virus (FMDV) Targeting the RNA-Dependent RNA Polymerase activity of 3Dpol [abstract]
(2010-03)
chemical library of compounds and have identified two compounds, 5-chloro-3-(thiophen-2-yl-sulfanylmethyl)-1-benzothiophene 1,1-dioxide (or C7F8) and N'1-thieno[2,3-d]pyrimidin-4-yl-4-chloro-1-benzenesulfonohydrazide (or C5D9) that inhibited the RNA...
Gene transfer technology : a tool for studying gene function and role in corneal pathogenesis [abstract]
(2010)
Transforming growth factor β (TGFb) is associated with many corneal pathologies, diseases and dystrophies. The function of TGFb in adult corneas cannot be studied using conventional transgenic approach because TGFb1 and TGFb2 deficient transgenic...
Patients with venous tromboembolism have higher prevalence of obstructive sleep apnea [abstract]
(2010-03)
327.2, 327.23, 780.5, 780.51, 780.53, 780.57, 786.03. Continuous data were expressed as means or medians and compared using the student t or the Mann-Whitney tests. Categorical variables were expressed as percentages and compared using the Chi...
Antitumor withanolides from Withania somnifera [abstract]
(2010)
for the treatment of arthritis, tumors, tuberculosis, chronic liver diseases and for immunomodulatory effects. Biological activity in this species is attributed to withanolides, a group of naturally occurring C28-steroidal lactones including withaferin A. During our...
SMAD-signaling inhibition : potential for developing newer treatments for corneal fibrosis [abstract]
(2010)
Transforming growth factor [beta] (TGFb) is known to cause fibrosis in the cornea following injury and/or infection. Effective reduction in corneal fibrosis has been reported by inhibiting TGFb activity. However, associated ...
Identifying angiotensin II effects on protein kinase B activation in insulin metabolic signaling [abstract]
(2010-03)
metabolic signaling event of Akt activation as it relates to Ang II alone was investigated. C2C12 mouse skeletal muscle cells were cultured in 60mm dishes (DMEM with 10% FBS, 1% penicillin/streptomycin) at 5% CO2 and 37 °C until ?80% confluent...
Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
PSC) from swine by reprogramming somatic cells with a combination of four factors (OCT4, SOX2, KLF4, C-MYC) delivered by retroviral transduction. The piPSC resembled FGF2- dependent human (h) ESC and are likely to advance swine as a model in biomedical...
Effect of a primed goal of patient safety on patient risk detection [abstract]
(2010)
The ability of intensive care unit (ICU) nurses to detect potential adverse events in critically ill patients is strongly influenced by the environment in which they function. Features of social environments, such as ...
SAHA : FDA approved histone deacetylase inhibitor demonstrates exceptionally high inhibition of corneal haze following PRK surgery in rabbit model [abstract]
(2010)
TGF[beta] induces the transformation of corneal keratocytes into fibroblasts and myofibroblasts resulting in the formation of corneal haze (scar) following injury. We investigated whether epigenetic modifications can prevent ...
Selective Laser Sintering and Freeze Extrusion Fabrication of Bioglass Bone Scaffolds [abstract]
(2010)
green scaffolds underwent binder burnout to remove the stearic acid binder and then sintered at temperatures between 6500C and 7000C. After sintering, the scaffolds were mechanically tested, achieving a maximum compressive strength of 16 MPa...
Protracted activation of the basal forebrain cholinergic neurons after binge ethanol exposure [abstract]
(2010)
Insomnia during alcohol withdrawal is a hallmark of alcohol dependency and a major cause of relapse in recovering alcoholics. The mechanism of insomnia in this patient population is poorly understood. Cholinergic neurons ...