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Gene transfer technology : a tool for studying gene function and role in corneal pathogenesis [abstract]
(2010)
Transforming growth factor β (TGFb) is associated with many corneal pathologies, diseases and dystrophies. The function of TGFb in adult corneas cannot be studied using conventional transgenic approach because TGFb1 and ...
AAV5-mediated targeted decorin gene therapy : effective and safe for corneal fibrosis [abstract]
(2010)
Corneal fibrosis is 3rd leading cause of global blindness according to WHO report. At
present, no agents are proven to clinically reduce corneal fibrosis without causing significant side effects. It was hypothesized that ...
SMAD-signaling inhibition : potential for developing newer treatments for corneal fibrosis [abstract]
(2010)
Transforming growth factor [beta] (TGFb) is known to cause fibrosis in the cornea following injury and/or infection. Effective reduction in corneal fibrosis has been reported by inhibiting TGFb activity. However, associated ...
Tissue-selective controlled decorin gene delivery in the rabbit cornea significantly retards corneal angiogenesis in vivo [abstract]
(2010)
Recent studies have shown that decorin gene therapy inhibits neovascularization in many non-ocular tissues. We tested the efficacy of decorin gene delivery into stroma with AAV5 to impede vascular endothelial growth factor ...