Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown. The basal forebrain (BF) cholinergic neurons play ...

Insomnia during alcohol withdrawal is a hallmark of alcohol dependency and a major cause of relapse in recovering alcoholics. The mechanism of insomnia in this patient population is poorly understood. Cholinergic neurons ...

Today's work pressure has lead people to curtail their sleep. However, all of the consequences of sleep deprivation are not clear. Histone acetylation is a key epigenetic mechanism responsible for controlling gene expression. ...

One of the most commonly observed characteristics of alcohol withdrawal is insomnia. Importantly, there is a strong association between insomnia and relapse to alcoholism. In a recent study, we have shown that insomnia in ...

Binge drinking is highly prevalent in the society especially among college students. It is often followed by a period of “hangover” which is defined as general discomfort consisting of heterogeneous behavioral and psychological ...

Nicotine (tobacco) addiction is a serious health issue and a leading cause of death. However, the mechanism of nicotine addiction is not fully understood. Previous reports suggest that nicotine induced activation of orexin ...