Now showing items 1-6 of 6
Getting over a hangover : how do wake promoting neurons in the basal forebrain affect ethanol induced sleep? [abstract]
Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown. The basal forebrain (BF) cholinergic neurons play ...
Nicotine reduces adenosine release in the lateral hypothalamus : a possible mechanism of its addiction [abstract]
Nicotine (tobacco) addiction is a serious health issue and a leading cause of death. However, the mechanism of nicotine addiction is not fully understood. Previous reports suggest that nicotine induced activation of orexin ...
Protracted activation of the basal forebrain cholinergic neurons after binge ethanol exposure [abstract]
Insomnia during alcohol withdrawal is a hallmark of alcohol dependency and a major cause of relapse in recovering alcoholics. The mechanism of insomnia in this patient population is poorly understood. Cholinergic neurons ...
Binge drinking causes sleep disruptions : a likelihood of hangover [abstract]
Binge drinking is highly prevalent in the society especially among college students. It is often followed by a period of “hangover” which is defined as general discomfort consisting of heterogeneous behavioral and psychological ...
Chronic ethanol exposure alters epigenetic mechanism in the basal forebrain [abstract]
One of the most commonly observed characteristics of alcohol withdrawal is insomnia. Importantly, there is a strong association between insomnia and relapse to alcoholism. In a recent study, we have shown that insomnia in ...
Sleep deprivation causes epigenetic changes in the basal forebrain [abstract]
Today's work pressure has lead people to curtail their sleep. However, all of the consequences of sleep deprivation are not clear. Histone acetylation is a key epigenetic mechanism responsible for controlling gene expression. ...