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Mechanistic understanding and potential targets for mustard gas keratopathy
(University of Missouri--Columbia, 2022)
Sulfur mustard gas (SM), a vesicating and alkylating agent, has been used as a warfare agent since World War I and recently in Syria. SM exposure causes severe corneal injury, pain, and irreversible blindness. The cornea ...
Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
(University of Missouri--Columbia, 2022)
Mineralocorticoid receptor (MR) signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity ...
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ...