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Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)
Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ...
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)
, and as we've seen with extensive HIV-1 studies, can be thrown into disarray through targeted drug design. The implications of this work stand to benefit the study of plant pararetroviruses and could greatly inform the study of HBV RT, which to this day has...
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)
Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ...
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ...
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ...
Influenza virus strategies to regulate S1P-metabolizing enzymes and evade host innate immunity for robust viral replication
(University of Missouri--Columbia, 2021)
Viral infection is a complex network of interactions involving the host defending itself against the virus and the virus attempting to subdue host defenses and utilize the cellular machinery to promote its replication. ...
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)
The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ...
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias ...
Virus interactions with the sphingolipid network : sphingosine kinase 2 in immunosuppression, immunopathology, and viral propagation
(University of Missouri--Columbia, 2020)
Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule known to regulate diverse cellular functions. S1P is metabolized by the sphingosine kinases (SphK) and S1P lyase (SPL). However, little is known about the role ...