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Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
-99m ([superscript 99][superscript-m]Tc), Copper-64 ([superscript 64 ]Cu) or Bismuth-213 ([superscript 213]Bi)....
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)
V gamma rays (81% intensity) suitable for single-photon emission computed tomography (SPECT) imaging. On the other hand, [212]Pb (t1/2 = 10.6 hours) decays by beta emission into [212]Bi (t1/2 = 60.6 minutes), which subsequently decays into stable [208]Pb...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Supramolecular chemists can be thought of as the architects of the nano-scale world. We are primary concerned with the design and construction of ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Measurement of radionuclides in biological tissues from occupationally exposed individuals
(University of Missouri--Columbia, 2022)
Keratinous materials have the potential to be used in criminal investigation of individuals who participate in nuclear smuggling or in the production of clandestine nuclear weapons. To develop the keratin biomonitor, its ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of ...
Determination and analysis of multiphoton excitation emissive species.: I,: Emission of PAHS in acidic medium,: II,: Multiphoton emission of possible PDT agents
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The exploitation of ultrafast laser properties has been recently increasing. Recent research in this lab demonstrated the ability of femtosecond pulses ...
Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals
(University of Missouri--Columbia, 2007)
Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 ...
Structural supramolecular constructs of spheres and tubes
(University of Missouri--Columbia, 2006)
This thesis examines four different molecular systems that are in part or substrates for larger structural motifs that resemble spheres or tubes. The first project used donut shaped cucurbituril and through functionalization ...
Energy transfer at gas-liquid interface : towards energetic materials
(University of Missouri--Columbia, 2007)
Physicochemical surface processes have great importance in the different fields of everyday life and science. Computational characterization of collisional energy transfer at a gasliquid interface is a helpful tool to ...
Reactivity of lesions derived from abasic (AP) sites in DNA
(University of Missouri--Columbia, 2021)
DNA is vital to cellular function. Therefore, maintaining the integrity of the structure of DNA is of the utmost importance. Damage to the DNA is unavoidable and can be detrimental to organisms. Abasic (Ap) sites are the ...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
The subject of this dissertation is the use of electronic structure calculations to examine and supplement the experimental observations of three different chemical systems. Both ab initio and DFT methods have been employed. ...
Structural and kinetic studies of human aldh7a1 and aldh9a1
(University of Missouri--Columbia, 2021)
of oxidoreductase enzymes that have critical roles in this regulation and detoxification. Misregulation of ALDH gene expression or mutations in the genes encoding for ALDHs lead to numerous disease pathologies. While extensive work has been conducted...
Synthesis, characterization, and reactivity of actinide complexes bearing An-E bonds (An = Th, U; E = P, As)
(University of Missouri--Columbia, 2021)
-metal phosphinidiide complexes of the form {(C5Me5)2Th[[mu]2-P(Mes)][[mu]2-P(H)Mes]M(L)n}2 (L = THF, Et2O), where computational (DFT) analysis and 31P NMR spectroscopy suggests significant Th-P multiple bond character. Reaction of (C5Me5)2Th[P(H)Mes]2 with CuMes in a 2...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Fluorescence sensing plays an important role in a wide variety of fields such as medical science, chemical biology, food industry and so on. Several new fluorescent probes were developed to target ...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
Supramolecular, self-assembled nanocapsules have shown the capability to encapsulate organic guests. Since most of the work was done previously in the solid state, the novelty of this research was its focus on probing ...
Radioanalytical multi-elemental analysis : new methodology and archaeometric applications
(University of Missouri--Columbia, 2010)
Several projects are covered in this dissertation: the application of instrumental neutron activation analysis (INAA) and rigorous statistical analyses to the sourcing of Egyptian limestone and Kenyan obsidian, and the ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...