Now showing items 1-4 of 4
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
DNA is the central molecule in cells. The correct function of cells depends on the structure of DNA. DNA damaging natural products often show cytotoxic or mutagenic properties, which many times land them medicinal value ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
toxic to human pancreatic carcinoma cell line (MiaPaCa) and fragments DNA extensively with an IC[subscript 50] of 50 nM. The elucidation of molecular mechanism behind the rapid depurination event might help to understand more about the molecule�s potent...
Investigations into the chemistry of protein tyrosine phosphatase redox regulation
(University of Missouri--Columbia, 2009)
Transmission of complex intracellular signals, such as those for glucose uptake or proliferation, is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible ...
Biologically relevant chemistry of sulfur heterocycles: from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)
Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ...