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Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)
Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ...
Metamorphism of the Wales Group and Moira Group on Prince of Wales and Dall Islands, southeastern Alaska
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This study examines the metamorphic history of the Proterozoic to Early Ordovician Wales Group and the newly-named Ordovician to Silurian Moira Group ...
Gene expression profiling of bovine ovarian follicular selection
(University of Missouri--Columbia, 2006)
Lack of, or abnormal, ovarian follicular development is a major factor associated with impaired fertility in mammals. However, development of new treatments is limited by our poor understanding of ovarian follicular ...
Analysis and modeling of direct selective laser sintering of two-component metal powders
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Direct Selective Laser Sintering (SLS) is an emerging technology of Solid Freeform Fabrication (SFF) that 3-D parts are built from the metal-based ...
Examination of metabolic and regulatory networks of desulfovibrio species
(University of Missouri--Columbia, 2004)
The sulfate-reducing bacteria are a morphologically diverse group of organisms characterized by the ability to couple the enzymatic reduction of sulfate to energy production and growth. This metabolic activity has profound ...
Molecular cloning and characterization of regulatory enzymes in threonine biosynthetic pathway from soybean
(University of Missouri--Columbia, 2007)
Soybeans (Glycine max [L.] Merr.) are a good source of protein and oil. Despite being a very good source of protein, soybeans nutritional value is limited by low proportion of sulfur amino acids methionine and cysteine ...
Fluorescence spectroscopy and parallel factor analysis of waters from municipal waste sources
(University of Missouri--Columbia, 2007)
location. Parallel Factor Analysis (PARAFAC) has recently been used to effectively model EEM data sets. This thesis continues the study of the EEM/PARAFAC technique by applying it to waters of municipal waste sources. Bi-weekly samples were collected over a...
Statistical analysis of multivariate interval-censored failure time data
(University of Missouri--Columbia, 2007)
A voluminous literature on right-censored failure time data has been developed in the past 30 years. Due to advances in biomedical research, interval censoring has become increasingly common in medical follow-up studies. ...
The effects of axotomy on the biophysical properties of reticulospinal neurons in larval lamprey
(University of Missouri--Columbia, 2006)
Following severe spinal cord injury (SCI), in adult higher vertebrates there is little or no axonal regeneration, and animals remain paralyzed below the lesion. In contrast, lower vertebrates such as the lamprey, following ...
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
-99m ([superscript 99][superscript-m]Tc), Copper-64 ([superscript 64 ]Cu) or Bismuth-213 ([superscript 213]Bi)....
Development of tailored preform processing technology for net-shape manufacturing of large monolithic structures
(University of Missouri--Columbia, 2007)
The aim of the present research effort involves exploration of a new processing approach, "Tailored Preform Processing (TPP)" technology for net-shape manufacturing of monolithic structures for the transportation industry. ...
Understanding students' technology appropriation and learning perceptions in online learning environments
(University of Missouri--Columbia, 2005)
Distance education has the unique characteristic of using technologies as the primary means of delivery of instruction and interaction. The present study contributes to research dedicated to explaining or predicting phenomena ...
Bayesian spatial data analysis with application to the Missouri Ozark forest ecosystem project
(University of Missouri--Columbia, 2006)
The first part studies the problem of estimating the covariance matrix in a star-shaped model with missing data. By introducing a class of priors based on a type of Cholesky decomposition of the precision matrix, we then ...
Effects of high fat loading on substrate utilization and performance during intermittent exercise in trained athletes
(University of Missouri--Columbia, 2008)
High intensity intermittent exercise is the most common form of exercise in competitive sport yet dietary factors that affect an athlete's performance in this capacity are rarely investigated. The purpose of this investigation ...
The validity of morphological features and osteological markers in reconstructing habitual activities
(University of Missouri--Columbia, 2007)
Bony morphological features have been used to reflect biomechanical behavioral patterns among archaeological populations. Of most recent ones is the anterior femoral curvature (AFC). It has been proposed as a valid indicator ...
A study of transcript profiling of soybean roots during nitrogen fixing symbiosis
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nodulation is a symbiotic association between a host plant and its bacterium. The result of this interaction is the formation of a novel organ, the ...
Three essays on stock market liquidity and earnings seasons
(University of Missouri--Columbia, 2009)
In these essays, I identify the effects of earnings seasons (i.e., the clustering of earnings releases), on stock market liquidity and asset pricing. In the first essay, I document strong seasonal regularities associated ...
Essays on closed end funds: disclosure, discounts and performance
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Closed end funds provide a unique asset class for academic research due to that fact that they typically trade at a price different from the Net Asset ...
Functional outcome and self-perceived overall health status following surgery to remove primary brain tumor
(University of Missouri--Columbia, 2008)
Impaired functional abilities, especially those associated with ambulation and standing balance, are common sequelae of brain tumors. A majority of research regarding the effectiveness of surgery in treating individuals ...
A ratiometric fluorometer for reduced sensitivity against solvent artifacts
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] When measuring fluorescence emission intensity, both the dye concentration and the optical absorption properties of the solvent influence the measured ...