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Elucidating the roles of the ATP7A copper transporter in cultured cells, tumor growth and metastasis
(University of Missouri--Columbia, 2013)
, connective tissue development, pigment formation, iron absorption and mobilization, integrity of the central nervous and immune systems. However, copper can also be toxic when present in excessive amounts, owing to its ability to facilitate reactive oxygen...
Molecular and cell biological studies of mammalian zinc transporters
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Zinc is an essential trace element in all organisms. The importance of the hZIP4 human zinc transporter is highlighted by its causative role in a ...
The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)
internalization. It is hypothesized that multiple di-leucines in the carboxy-terminus of ATP7A are involved in the internalization of the protein. The study presented in this thesis, identified a second di-leucine motif in ATP7A that is a bonafide sorting signal...
Regulation of copper homeostasis and inflammation in microglial cells
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Disturbed copper homeostasis has been shown to implicate in the pathogenesis of AD, as evidenced by high accumulation of copper in the senile plaques. ...
Functional studies of hCTR1, a high affinity human copper and cisplatin transporter
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Copper is an essential nutrient. The uptake of copper is mediated by the human copper transporter 1 (hCTR1) protein at the plasma membrane. Elevated ...
Inflammation and hypoxia : novel regulators of mammalian copper homeostasis in macrophages
(University of Missouri--Columbia, 2008)
Copper is an essential cofactor of enzymes involved in a variety of important metabolic processes including ATP production, iron transport, and antioxidant defense. The maintenance of copper homeostasis requires a balance ...