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Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Rhenium complexes with O, N, S ligands
(University of Missouri--Columbia, 2006)
The main focus of this thesis is the synthesis and characterization of nonradioactive rhenium complexes containing O, N, S ligands. Chapter 2 describes the rhenium labeling of four somatostatin analogues. Confirmation for ...
Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals
(University of Missouri--Columbia, 2007)
Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
. These systems focus on differences in chelating atoms and hydrophobicity as methods for optimization of labeling conditions for [superscript 105]RH.-From public.pdf...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of ...
Selection of small pretargeting peptides with affinity for radiochelates and separation and purification of radiolanthanides
(University of Missouri--Columbia, 2014)
The first objective of this dissertation was to develop metallated chelates with Michael acceptor groups for selecting small peptides from a random phage display library (RPL). The selection is for cysteine bearing peptides, ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ...
Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)
Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ...