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Physiological responses of adipose tissue to different models of physical activity and inactivity
(University of Missouri--Columbia, 2013)
Childhood is a critical time of growth, and decisions made during this time lead to positive and negative health consequences, specifically pertaining to adiposity. There is convincing evidence that children who are ...
Examination of nucleus accumbens mechanisms underlying the motivation for physical activity
(University of Missouri--Columbia, 2017)
between HVR and LVR, as well as the influence of dopamine on opioid-induced changes in voluntary wheel running. Mu-opioid receptor expression and function was increased in the nucleus accumbens (NAc) of HVR compared to LVR. Likewise, naltrexone injection...
The role of resistance exercise training & IGF-1 signaling in the amelioration of mild cognitive impairment in female Wistar rats
(University of Missouri--Columbia, 2021)
Mild cognitive impairment increases risk for dementia. One therapeutic intervention that is reported to ameliorate cognition in patients with mild cognitive impairment is resistance exercise. However, the underlying ...
Mechanisms regulating skeletal muscle satellite cell cycle progression
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Skeletal muscle fibers are multinucleated with each myonucleus capable of governing a finite cytoplasmic volume. In healthy skeletal muscle, myonuclear ...
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ...
Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In aged skeletal muscle, impairments in the regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs), ...
The molecules that move us : evaluating potential genetic and molecular determinants of physical activity motivation
(University of Missouri--Columbia, 2019)
untamed and at the forefront of our public health interests. For the first time in human history, engaging in physical activity is essentially voluntary, a choice that [about] 97 [percent] of U.S. adults fail to meet in terms of the U.S. Physical Activity...
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Physical activity has played an essential role in the evolution of humans and the development of the human brain. Therefore, it comes as no surprise that the modern-day pandemic levels of sedentarism ...
Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ...
Physical inactivity induced dysregulation of skeletal muscle and adipose tissue metabolism
(University of Missouri--Columbia, 2005)
There has been a precipitous decline in the daily physical activity in humans that has been accompanied by an epidemic rise in the incidence of obesity and type II diabetes. This rapid decline in physical activity in humans ...
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)
The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ...
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)
The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ...