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Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
and polymers which can self-organize into a helical conformation have been extensively studied. Such studies have not only led to much better understanding of the principles behind noncovalent folding, but also brought about a number of exciting applications...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Positron interactions with oriented polymers and with chiral quartz crystals
(University of Missouri--Kansas City, 2017)
Positron annihilation in various materials has been applied to characterize
microstructure for decades. In this work, PALS was used to study material nanostructure,
with a focus on the size and density of free volume ...
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)
. Experimentally, we have used space-charge-limited current (SCLC) analysis to extract the charge carrier mobility in a-BC:H thin films. To better describe the extracted charge carrier mobility, we have presented an extension of SCLC theory to include negative...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Photoemission Spectroscopy Studies of New Topological Insulator Materials
(2015-08-04)
As the size of a solid shrinks, the ratio of surface area to bulk volume grows and
surface effects become more important. In a world where technologies advance with the
shrinking size of electronic devices, one phase of ...
Design, synthesis and evaluation of novel intercalator analogs targeting therapeutically important polymerases and folded RNA
(2013)
Polymerases and ribonucleic acids have been found to play major roles in the
causation and progression of several diseases. Targeting such important therapeutic targets
using small molecules can help achieve their specific ...
Protein production and applications of NMR in pharmaceutical sciences
(2014-08-28)
The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ...
Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
(2014)
Due to the high tendency to form π-stacked ordered phases, polycyclic aromatic hydrocarbons (PAHs) are attractive building blocks for the assembly of conjugated systems for electronic applications. The body of this ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Effects of Selected Contaminants on the Physical, Chemical, and Geotechnical Properties of Aquifer Solid
(2014)
contaminants on the hydraulic conductivity of sand. Bulk sand samples from the Missouri River Valley aquifer— a major source of groundwater supply in the U.S. Midwest— were collected for this study. Sand samples, representing the aquifer and vadose zone...
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)
Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Evaluation of Cement-Based Reactive Media for Contaminant Remediation
(University of Missouri -- Kansas City, 2018)
Water contaminated with heavy metals, arsenic, and other industrial pollutants
poses a severe risk to human health. Reactive media present an opportunity to intercept
contaminants but have high material or environmental ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Raman, Infrared and Microwave Spectra, Conformational Stability, R₀ Structural Parameters and Vibrational Assignments of Some Organoamines, Organophosphines, Alcohols And Substituted Four And Five Membered Rings
(2014)
The infrared and Raman spectra of compounds with amino, phosphours, silane and hydroxyl functional groups, as well as some with cyclic skeletal structures have been recorded of the gas and in condensed phases. Temperature ...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...