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Protein production and applications of NMR in pharmaceutical sciences
(2014-08-28)
The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ...
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)
. Experimentally, we have used space-charge-limited current (SCLC) analysis to extract the charge carrier mobility in a-BC:H thin films. To better describe the extracted charge carrier mobility, we have presented an extension of SCLC theory to include negative...
Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
and polymers which can self-organize into a helical conformation have been extensively studied. Such studies have not only led to much better understanding of the principles behind noncovalent folding, but also brought about a number of exciting applications...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Mathematical Analysis of Compressive/Tensile Molecular and Nuclear Structures
(2015-06-19)
Mathematical analysis in chemistry is a fascinating and critical tool to explain
experimental observations. In this dissertation, mathematical methods to present
chemical bonding and other structures for many-particle ...
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)
are summarized in Chapters 4-5 and 6, respectively. In Chapters 1 and 2, an overview of the aims and scope of this study, and a literature review of the two parts of this dissertation is extensively discussed. In Chapter 3, it was hypothesized that fluorine 19...
Effects of Selected Contaminants on the Physical, Chemical, and Geotechnical Properties of Aquifer Solid
(2014)
contaminants on the hydraulic conductivity of sand. Bulk sand samples from the Missouri River Valley aquifer— a major source of groundwater supply in the U.S. Midwest— were collected for this study. Sand samples, representing the aquifer and vadose zone...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Design, synthesis and evaluation of novel intercalator analogs targeting therapeutically important polymerases and folded RNA
(2013)
Polymerases and ribonucleic acids have been found to play major roles in the
causation and progression of several diseases. Targeting such important therapeutic targets
using small molecules can help achieve their specific ...
Raman, Infrared and Microwave Spectra, Conformational Stability, R₀ Structural Parameters and Vibrational Assignments of Some Organoamines, Organophosphines, Alcohols And Substituted Four And Five Membered Rings
(2014)
The infrared and Raman spectra of compounds with amino, phosphours, silane and hydroxyl functional groups, as well as some with cyclic skeletal structures have been recorded of the gas and in condensed phases. Temperature ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ...