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Which drugs are most effective for moderate to severe depression in adolescents?
(Family Physicians Inquiries Network, 2008)
Fluoxetine is the only selective serotonin-reuptake inhibitor (SSRI) approved by the US Food and Drug Administration (FDA) to treat depression in children 8 years of age and older; it also has the most favorable benefit-to-risk profile compared...
What is the most effective and safe malaria prophylaxis during pregnancy?
(Family Physicians Inquiries Network, 2008)
the incidence of low birth weight and perinatal death in women having their first or second baby (strength of recommendation [SOR]: A, based on systematic review of consistent, good-quality patient-oriented evidence)....
What's the most effective treatment for giardiasis?
(Family Physicians Inquiries Network, 2008)
A single 2-g dose of tinidazole is the best treatment (strength of recommendation [SOR]: A, based on meta-analysis). Other drugs, such as nitazoxanide, metronidazole, mebendazole, and albendazole, can also be used (SOR: A, based on randomized...
Does heat or cold work better for acute muscle strain?
(Family Physicians Inquiries Network, 2008)
Cryotherapy is better than heat for treating acute muscle strain (strength of recommendation [SOR]: C, consensus, usual practice, and expert opinion). Insufficient patient-oriented evidence exists regarding use of heat to treat acute soft...
Empirically derived profiles of classroom management strategies and related student outcomes : a latent profile analysis
(University of Missouri--Columbia, 2013)
profile of classroom management strategies. Implications of these findings are discussed for school-based school psychological practice....
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
The relationship between teacher classroom management profiles and related teacher stress: a latent profile analysis
(University of Missouri--Columbia, 2022)
The study was a latent profile analysis of teacher classroom management styles. The data used were derived from a randomized control trial that examined the efficacy of the CHAMPS behavior management program on middle school teachers. There were 187...
Explainable artificial intelligence for patient stratification and drug repositioning
(University of Missouri--Columbia, 2021)
the inter- and intra-heterogeneity within a cancer type and among cancer types. Patients' phenotypic and genotypic data was utilized with a heterogeneous knowledge base because it gives a multi-view perspective for finding new indications for drugs outside...
What is the best workup for hypocalcemia?
(Family Physicians Inquiries Network, 2008)
Unexplained hypocalcemia can usually be diagnosed by a limited number of serum tests when the cause isn't obvious from the history (recent neck surgery or renal failure): calcium corrected for serum albumin); creatinine; ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
pentablock polymers based thermosensitive hydrogel by incorporating PLA block in the center of PEG-PCL-PEG. These polymers were characterized by 1H NMR, GPC, and FT-IR. The effect of block composition on the sol-gel transition, crystallinity, and drug release...
US Regulation of Agricultural Biotechnology : An Overview
(AgBioForum, 2000)
Three federal agencies -- the United States Department of Agriculture (USDA), Environmental Protection Agency (EPA) and Food and Drug Administration (FDA) -- share primary responsibility for regulating biotechnology in the United States...
Representative Bureaucracy and Racial Profiling in Missouri
(University of Missouri--Kansas City, 2017)
There have been inquiries regarding the extent, nature, and causes of racial
profiling. Numerous studies have been and continue to explore whether and how the
experience of people of color differ from those of majorities ...
The black inside the blue : black law enforcement officers' perceptions of racial profiling in Missouri
(University of Missouri--Columbia, 2018)
Nationally, law enforcement agencies are under tremendous scrutiny in reference to racial profiling. A gap exists in knowledge of Black law enforcement officers? in Missouri perceptions of racial profiling. Missouri has experienced a...
Refining school mental health screening using mixture modeling : evaluation for use in applied settings
(University of Missouri--Columbia, 2020)
Universal socioemotional and behavior screening procedures continue to gain momentum and adoption in schools; however, a major research-to-practice gap remains in translating these data into meaningful interventions for identified students. Despite...
Automobile Searches: The Gap Between the Theory and Praxis of Law
(University of Missouri--Kansas City, 2010)
The overrepresentation of racial and ethnic minorities at every stage of the criminal justice process has brought about legislative, judicial, and voluntary data explorations of law enforcement practices. As the gatekeepers to the criminal justice...
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)
) based nanoparticle (NP) delivery system suitable
for the encapsulation of tenofovir (TFV) is designed and optimized. The physicochemical
characteristics of the NPs including encapsulation efficiency (EE%), diameter,
morphology, in vitro drug release...
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)
) in HAART has substantially improved clinical outcomes of HIV infected patients. However complete eradication of virus poses an unmet goal. Major challenge with current anti-HIV drug regimen is the inability of PIs to attain sufficient concentrations...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
(2014-08-28)
secondary aim of this investigation we developed novel pentablock (PB) copolymer nanoparticles of pazopanib for treatment of ocular neovascularization. Our results indicated that PB copolymer based drug delivery systems can serve as a platform technology...
The Ins and Outs and ABCs of Antifungal Drug Transport: Characterizing the Role of Membrane Transporters in Pathogenic Fungi
(2016)
targets may be discovered with a better understanding of basic fungal biological processes. New or improved fungal infection treatment strategies may stem from a more complete knowledge of fungal response to drug treatment, worldwide trends of fungal...