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Antidepressant Medications in Pregnancy
(Family Physicians Inquiries Network, 2004)
have indicated increased short-term neonatal adverse effects after exposure to antidepressants in the third trimester.[Strength of recommendation: B, based on cohort studies.]...
Which drugs are most effective for moderate to severe depression in adolescents?
(Family Physicians Inquiries Network, 2008)
Fluoxetine is the only selective serotonin-reuptake inhibitor (SSRI) approved by the US Food and Drug Administration (FDA) to treat depression in children 8 years of age and older; it also has the most favorable benefit-to-risk profile compared...
What is the most effective and safe malaria prophylaxis during pregnancy?
(Family Physicians Inquiries Network, 2008)
the incidence of low birth weight and perinatal death in women having their first or second baby (strength of recommendation [SOR]: A, based on systematic review of consistent, good-quality patient-oriented evidence)....
What medication best prevents migraine in children?
(Family Physicians Inquiries Network, 2003)
Propranolol, valproic acid, and amitriptyline are effective prophylaxis for migraine in children to varying degrees, are widely available, and have a reasonable safety profile (strength of recommendation [SOR]: B, based on either single randomized...
What's the most effective treatment for giardiasis?
(Family Physicians Inquiries Network, 2008)
A single 2-g dose of tinidazole is the best treatment (strength of recommendation [SOR]: A, based on meta-analysis). Other drugs, such as nitazoxanide, metronidazole, mebendazole, and albendazole, can also be used (SOR: A, based on randomized...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Is nedocromil effective in preventing asthmatic attacks in patients with asthma?
(Family Physicians Inquiries Network, 2004)
In general, about 50% to 70% of patients respond to nedocromil (SOR: A, multiple RCTs and meta-analyses). Unfortunately, which patients respond is not predictable from clinical parameters. Nedocromil is worth trying in ...
The relationship between teacher classroom management profiles and related teacher stress: a latent profile analysis
(University of Missouri--Columbia, 2022)
The study was a latent profile analysis of teacher classroom management styles. The data used were derived from a randomized control trial that examined the efficacy of the CHAMPS behavior management program on middle school teachers. There were 187...
Empirically derived profiles of classroom management strategies and related student outcomes : a latent profile analysis
(University of Missouri--Columbia, 2013)
profile of classroom management strategies. Implications of these findings are discussed for school-based school psychological practice....
Explainable artificial intelligence for patient stratification and drug repositioning
(University of Missouri--Columbia, 2021)
the inter- and intra-heterogeneity within a cancer type and among cancer types. Patients' phenotypic and genotypic data was utilized with a heterogeneous knowledge base because it gives a multi-view perspective for finding new indications for drugs outside...
Does heat or cold work better for acute muscle strain?
(Family Physicians Inquiries Network, 2008)
Cryotherapy is better than heat for treating acute muscle strain (strength of recommendation [SOR]: C, consensus, usual practice, and expert opinion). Insufficient patient-oriented evidence exists regarding use of heat to treat acute soft...
When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis?
(Family Physicians Inquiries Network, 2006)
of joint function for patients with rheumatoid arthritis, when compared with nonselective NSAIDs. The COX-2 selective NSAIDs also have a better gastrointestinal safety profile in short-term (6-12 month) treatment (strength of recommendation [SOR]: A, based...
Representative Bureaucracy and Racial Profiling in Missouri
(University of Missouri--Kansas City, 2017)
There have been inquiries regarding the extent, nature, and causes of racial
profiling. Numerous studies have been and continue to explore whether and how the
experience of people of color differ from those of majorities ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
pentablock polymers based thermosensitive hydrogel by incorporating PLA block in the center of PEG-PCL-PEG. These polymers were characterized by 1H NMR, GPC, and FT-IR. The effect of block composition on the sol-gel transition, crystallinity, and drug release...
Is the long-term use of proton pump inhibitors safe?
(Family Physicians Inquiries Network, 2004)
Long-term use of proton pump inhibitors (PPIs) appears safe, resulting in no clinically relevant adverse effects (strength of recommendation: B, based on nonsystematic reviews, cohort studies, or low-quality randomized controlled trials...
When should travelers begin malaria prophylaxis?
(Family Physicians Inquiries Network, 2007)
Travelers should start on chloroquine 1 to 2 weeks before entering an area without chloroquine resistance (strength of recommendation [SOR]: C, based on expert opinion). In areas with chloroquine-resistant Plasmodium falciparum, travelers will need...
Do statins reduce the risk of stroke?
(Family Physicians Inquiries Network, 2004)
reduce the risk of ischemic stroke for patients with coronary disease or equivalents (such as diabetes or peripheral artery disease), including patients who have a normal fasting lipid profile (SOR: A, based on RCT). For patients with ischemic stroke who...
What is the role of tacrolimus and pimecrolimus in atopic dermatitis?
(Family Physicians Inquiries Network, 2005)
When the standard therapies -- mild topical
corticosteroids and moisturizers -- fail in the
treatment of atopic dermatitis, patients are left with few proven remedies. The recently introduced topical immunosuppressive ...
What are effective medical treatments for adults with acute migraine?
(Family Physicians Inquiries Network, 2006)
Medications collectively referred to as "triptans" (eg, sumatriptan, naratriptan, etc) have been shown to be effective for acute migraine (strength of recommendation [SOR]: A). Nonsteroidal anti-inflammatory drugs (NSAIDs)--including aspirin...
The black inside the blue : black law enforcement officers' perceptions of racial profiling in Missouri
(University of Missouri--Columbia, 2018)
Nationally, law enforcement agencies are under tremendous scrutiny in reference to racial profiling. A gap exists in knowledge of Black law enforcement officers? in Missouri perceptions of racial profiling. Missouri has experienced a...