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Does tranexamic acid reduce mortality in women with postpartum hemorrhage?
(Family Physicians Inquiries Network, 2019)
Q: Does tranexamic acid reduce mortality in women with postpartum hemorrhage? EVIDENCE-BASED ANSWER: Yes. When used in conjunction with the standard of care, 1 g intravenous (IV) tranexamic acid given 1 to 3 hours after delivery is associated with a...
Is aspirin effective for primary prevention of colon cancer?
(Family Physicians Inquiries Network, 2010)
Aspirin probably shouldn't be used for routine prevention because of its potential risks (strength of recommendation [SOR]: B, systematic review of inconsistent evidence). However, aspirin is likely to be effective for secondary prevention...
Does evidence support the use of supplements to aid in BP control?
(Family Physicians Inquiries Network, 2020)
Q: Does evidence support the use of supplements to aid in BP control? Evidence-based answer: Yes. A number of well-tolerated natural therapies have been shown to reduce systolic and diastolic blood pressure (BP). (See TABLE1-8 for summary.) However...
How best to help kids lose weight
(Family Physicians Inquiries Network, 2010)
Screen children and adolescents for obesity and offer them multifaceted weight loss interventions, based on new evidence (and a recent US Preventive Services Task Force [USPSTF] recommendation) of their effectiveness. Consider adding a weight loss...
What's the best way to screen for anxiety and panic disorders?
(Family Physicians Inquiries Network, 2007)
The GAD-7 has the best evidence and utility in the primary care setting for generalized anxiety disorder (strength of recommendation [SOR]: A), while the proprietary Quick PsychoDiagnostics Panel (QPD) has the best operating characteristics...
Does a low-fat diet help prevent breast cancer?
(Family Physicians Inquiries Network, 2007)
No. Studies show no evidence that reducing dietary fat decreases a woman's risk of developing postmenopausal breast cancer within the subsequent 14 years (strength of recommendation [SOR]: B, based on large heterogeneous prospective cohort studies...
What are the current treatment and monitoring recommendations for hepatitis C virus (HCV)?
(Family Physicians Inquiries Network, 2001)
evidence shows that treatment with PEG-interferon alpha-2b and ribavirin with weight-based dosing achieved an 82% sustained viral response. (Grade of recommendation: A [dual therapy]; D [all other recommendations].)...
Does spinal manipulation relieve back pain?
(Family Physicians Inquiries Network, 2010)
Spinal manipulation therapy (SMT) reduces lower back pain and improves the ability to perform everyday activities more than sham therapies (strength of recommendation [SOR]: A, multiple randomized controlled trials [RCTs] ...
How best to treat agitation in patients with irreversible dementia?
(Family Physicians Inquiries Network, 2013)
Atypical antipsychotics modestly reduce agitation compared with placebo but have significant adverse effects (strength of recommendation [SOR]: A, systematic reviews of randomized controlled trials [RCTs]). Haloperidol ...
Is therapy based on endoscopy results better than empiric therapy for dyspepsia?
(Family Physicians Inquiries Network, 2005)
In the initial management of dyspepsia for patients without "alarm" symptoms (weight loss, recurrent vomiting, dysphagia, anemia, evidence of bleeding, onset of dyspepsia after age 45 years), therapy based on the results of early endoscopy...
Does red wine reduce cardiovascular risks?
(Family Physicians Inquiries Network, 2010)
evidence exists to determine whether wine reduces cardiovascular risk more than other alcoholic beverages....
How useful are genital exams during boys' sports physicals?
(Family Physicians Inquiries Network, 2010)
Examination may be useful to identify hernia but not testicular cancer. Insufficient evidence exists to recommend for or against screening genital exams for boys playing sports. Given the low risk of harm, screening for hernias as a part of a...
What is the best treatment for infants with colic?
(Family Physicians Inquiries Network, 2006)
Infantile colic, defined as excessive crying in an otherwise healthy baby, is a distressing phenomenon, but there is little evidence to support the many treatments offered. Several small studies report some benefit from use of a hypoallergenic...
What screening tests should you use to evaluate a man with low testosterone?
(Family Physicians Inquiries Network, 2008)
Obtain a repeat morning testosterone level, as well as levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin to help understand the cause of low testosterone when there is a lack of adequate empiric evidence to guide...
Does a low-salt diet reduce morbidity and mortality in congestive heart failure?
(Family Physicians Inquiries Network, 2002)
No randomized controlled trials (RCTs) have addressed the independent role of sodium restriction in the morbidity or mortality of congestive heart failure. However, current guidelines recommend sodium restriction for ...
How effective is spironolactone for treating resistant hypertension?
(Family Physicians Inquiries Network, 2019)
Q: How effective is spironolactone for treating resistant hypertension? EVIDENCE-BASED ANSWER: VERY EFFECTIVE. Spironolactone reduces systolic blood pressure (SPB) by 11 to 17 mm Hg and diastolic blood pressure (DPB) by up to 6 mm Hg in patients...
Which smoking cessation interventions work best?
(Family Physicians Inquiries Network, 2011)
Nicotine replacement therapy (NRT), bupropion, nortriptyline, clonidine, and varenicline are all effective, although insufficient evidence exists to recommend one intervention over another (SOR: A, systematic reviews). Effective nonpharmacologic...
What is the evaluation and treatment strategy for Raynaud's phenomenon?
(Family Physicians Inquiries Network, 2005)
Raynaud's phenomenon is diagnosed by history,
which also plays a key role in distinguishing
primary from secondary Raynaud's phenomenon
(strength of recommendation [SOR]: C, based
on expert opinion). The initial treatment includes conservative...
Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression?
(Family Physicians Inquiries Network, 2022-07)
Q: Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression? Evidence-based answer: YES. Augmentation with second-generation antipsychotics, especially aripiprazole and quetiapine, appears to be effective...
What's the best approach to diagnosing food allergies in infants?
(Family Physicians Inquiries Network, 2010)
A well-designed oral food challenge (OFC) is the most reliable diagnostic test for infants whose clinical history and physical examination suggest a specific food allergy (strength of recommendation [SOR]: C, consensus ...