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Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications
(2013)
Valvular complications and atherosclerosis contribute to the majority of the
cardiovascular disease related deaths worldwide. In this thesis project the role of
normative tissue mineral concentrations in native and ...
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)
Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B,
(±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are
described. The 5,6,7-tribromoindole was ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
therefore, we have first determined an interaction of moxifloxacin with efflux (MDR1 and MRP2) transporters. Our results provides direct evidence that moxifloxacin is an overlapping substrate of MDR1 and MRP2 efflux transporters. Since, literature has...
Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
(2021)
drawbacks which hamper etoposide activity. The central hypothesis of this work is to enhance etoposide (VP-16) solubility, dissolution, and improve its antitumor activity using emerging formulations strategies such as complexation and nanotechnology. To test...
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)
-binding proteins (PBPs) are ubiquitous and essential enzymes necessary for cell wall biosynthesis. PBPs are broadly classified as low molecular mass (LMM) and high molecular mass (HMM) based on their molecular weight. Although all PBPs share a set of highly...
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)
(TB) (PCL-PEG-PCL, B-A-B) and PB (PLA-PCL-PEG-PCL-PLA (C-B-A-B-C) and PEG-PCL-PLA-PCL-PEG (A-B-C-B-A)) copolymers based thermosensitive gelling polymers. We have observed distinct effect of block arrangement and molecular weights of block copolymers...
Uranium Oxides for Solid-State Direct-Conversion Neutron Detection
(2020)
to achieve absorption probabilities of a few percentages: 1.5–4% for 10 MeV neutrons for natural uranium oxides, ∼2% for 1 MeV neutrons for ²³⁵U-based uranium oxides, and 7–9% for thermal neutrons for natural uranium oxides, assuming each detector is 1 cm...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Evaluation of Cement-Based Reactive Media for Contaminant Remediation
(University of Missouri -- Kansas City, 2018)
Water contaminated with heavy metals, arsenic, and other industrial pollutants
poses a severe risk to human health. Reactive media present an opportunity to intercept
contaminants but have high material or environmental ...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
microscopy. The NP have an average mean diameter of 250 nm, maximal EE% of 16.1% and 37.2% for TNF and TDF, respectively. There is a 4-fold increase in drug release rate from the 75% S-100 NP in the presence of SFS over 72 h. At a concentration up to 10 mg...
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis intermediates. Retention...
Ab initio computational applications of electronic structure and spectroscopic Properties of bulk Crystalline materials
(2013)
-ray absorption near edge structure (XANES) and optical dielectric functions] of elemental boron were systematically studied using an ab initio orthogonalized linear combination of atomic orbitals (OLCAO) method. Based on available experimental data...
Plasma-enhanced molecular layer deposition (PEMLD) of boron carbide dielectrics from carboranes for interconnect and patterning applications
(2022)
-level interconnects were introduced that require complex process. Such processes require multiple materials that can act as diffusion barriers, copper capping layers, etch stops, hard masks, etc. Currently, silicon-based materials are being used to fulfill...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
roles in many biological systems and processes. Amino acids are polar analytes and are difficult to separate on traditional silica based stationary phases in reverse phase chromatography to allow accurate quantification in their natural form. In part I...
Light-activated biomacromolecules
(2013)
Biomacromolecules, mainly nucleic acids and proteins, are involved in
every cellular process and therefore their aberrant level or function is linked with
most of the diseases. Controlling these macromolecules using light ...
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)
Amorphous hydrogenated boron carbide (a-BC:H) is one of a very limited number of neutron-sensitive materials. It has been studied over the last three decades for solid-state thermal neutron detection due to its high ...
Ab Initio Study of Amorphous Zeolitic Imidazolate Framework (A-ZIF) and Pyrophosphate crystals
(2020)
due to the sudden formation of N-N bond pairs. Systematic expansion of a-ZIF retains the framework softness until it fractures at high strain. Based on the expansion data, we propose an empirical formula for super-soft materials, which is in line...