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Synthesis and Electrocatalytic Properties of Structure Engineered First-Row Transition Metal Derivatives
(University of Missouri--Kansas City, 2018)
Hydrogen is a green energy carrier, producing only water when combusted, and a
hydrogen economy has been considered the ideal green economy for human society. Water
electrolysis can produce high-purity hydrogen on a ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)
,
there is an urgent need to develop a formulation with proper vaginal retention time for the
topical application of anti-HIV microbicides. The aim of this dissertation is to test the
hypothesis that a mucoadhesive polymer based nanomedicine can prolong the contact...
Evaluation of Cement-Based Reactive Media for Contaminant Remediation
(University of Missouri -- Kansas City, 2018)
Water contaminated with heavy metals, arsenic, and other industrial pollutants
poses a severe risk to human health. Reactive media present an opportunity to intercept
contaminants but have high material or environmental ...
Photoemission Spectroscopy Studies of New Topological Insulator Materials
(2015-08-04)
As the size of a solid shrinks, the ratio of surface area to bulk volume grows and
surface effects become more important. In a world where technologies advance with the
shrinking size of electronic devices, one phase of ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)
Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ...
Electrochemical Analysis of Oxidation of Primary Amines to Ketones with 3,5-Di-Tert-Butyl-1,2Benzoquinone
(2022)
Electrochemical techniques have been used extensively to study electrode reactions and
the coupled chemical-electrochemical reactions. Moreover, the concentration of redox active
species in many of the redox reactions ...
Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
(2014)
applications. Specifically, two imine-based shape-persistent macrocycles containing triphenylene building blocks have been synthesized. Their stable conformations are predicted by quantum mechanical calculations and confirmed by 2D NOESY NMR measurements...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Uranium Oxides for Solid-State Direct-Conversion Neutron Detection
(2020)
to achieve absorption probabilities of a few percentages: 1.5–4% for 10 MeV neutrons for natural uranium oxides, ∼2% for 1 MeV neutrons for ²³⁵U-based uranium oxides, and 7–9% for thermal neutrons for natural uranium oxides, assuming each detector is 1 cm...
Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics
(2021)
In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
roles in many biological systems and processes. Amino acids are polar analytes and are difficult to separate on traditional silica based stationary phases in reverse phase chromatography to allow accurate quantification in their natural form. In part I...
Development and Evaluation of 3D-Printed Cardiovascular Stents
(2022)
.30±0.10 x 10-4/hr for HEMA, and 98.2±0.3% and 0.11±0.04 x 10-4/hr for HEMA-0.35MeGO. The addition of MeGO significantly (p<0.001) enhanced the stiffness of hydrogel inks for 3D stents, indicating Young’s moduli of 0.22±0.01x10-2 MPa and 0.41±0.01x10-2 MPa...
Plasma-enhanced molecular layer deposition (PEMLD) of boron carbide dielectrics from carboranes for interconnect and patterning applications
(2022)
-level interconnects were introduced that require complex process. Such processes require multiple materials that can act as diffusion barriers, copper capping layers, etch stops, hard masks, etc. Currently, silicon-based materials are being used to fulfill...
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)
Amorphous hydrogenated boron carbide (a-BC:H) is one of a very limited number of neutron-sensitive materials. It has been studied over the last three decades for solid-state thermal neutron detection due to its high ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)
Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry,
University of Missouri-Kansas City.
Heterocyclic chemistry is one of the most valuable sources of novel compounds with
diverse biological ...
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to design and optimize a nanoformulations
(nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for
HIV prevention in women.
In chapters 1 and ...