Now showing items 1-3 of 3
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor cells. Selective...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
. Results demonstrated that in general Ga-67 conjugates had higher binding affinity, similar stability in human serum, and vast differences in both hydrophobicity and in vivo biodistribution profiles....
The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors
(University of Missouri--Columbia, 2008)
Heavy metals in the environment such as Cd, Hg and Pb are toxic to life forms. They can enter the ecological system through both natural and industrial sources. By developing chemical sensors that can detect these metals, ...