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Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
expression and examine its effects on tumor cell invasiveness and growth, and (2) for type-1 diabetes is to develop a stable transgene delivery system that can infect dividing as well as quiescent cells, such as pancreatic islets. In chapter 1 and 2...
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to present various approaches for treatment cancer,
which is the leading cause of death worldwide. Compared to other disease, cancer has many
unique biological characteristics that ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...