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Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
and biological applications. As a two-dimensional material, molybdenum disulfide (MoS2) has drawn wide attention due to its fascinating properties and exciting application prospects. However, in order to access these properties, which lie within single- or few...
Synthesis and characterization of cerium (III) and (IV) compounds
(University of Missouri--Columbia, 2022)
Treatment of Cp*2CeCl2K with various aryl alcohols and amines produces Cp*2Ce(O- 2,6-iPr2C6H3) and Cp*2Ce(N(C6H5)2). The crystallographic structures are presented as well as their fluorescence. Absorbance measurements ...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
[kappa][subscript 0]. The model was also combined with MONTEBURNS and ORIGEN to test the feasibility of Mo[superscript 99] production at MURR from fissioning LEU. Results from a 5-gram low-enriched uranium target show predictions of Mo[superscript 99] end...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution...
Oxidative molecular layer deposition of redox-active thin-film polymers
(University of Missouri--Columbia, 2022)
Thin film materials research for a more sustainable future is growing rapidly and new techniques for depositing these films are beginning to surface. One such technique is highlight in this body of work using gaseous ...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
to increasing spectral resolution as excitation wavelength increases, multi-excitation datasets are notoriously difficult to align spectral features. In addition, the subtraction of the water band can be difficult when relying on an internal intensity standard...
Machine learning for mixed quantum-classical dynamics and transition metal chlorides oxidation potential via density functional theory
(University of Missouri--Columbia, 2023)
between these matters governs the study of excited state molecules. Many natural processes, such as photosynthesis,5 to important technologies, such as photovoltaic cells6,7 and spectral analysis8-10 arise from understanding these interactions. When...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic data (UV...
Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
elements of Mg, Mn, Fe, Cu, Zn and Mo levels in the plasma from the tobacco budworm, Heliothis virescens, following infection of the insect with a baculovirus (Helicoverpazea single nucleopolyhedrovirus (HzSNPV)) and bacteria (Micrococcus lysodeikticus...
Comparison of hyperbranched and dendritic polymers with fluorescent reporter molecules
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hyperbranched polymers containing a core region are a relatively new class of polymers with many similarities to dendrimers, including their proposed ...
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)
through numerous cellular internalization studies undoubtedly revealed that Res-PdNP-4 nanoparticles can be internalized into prostate cancer cells via laminin receptor-mediated endocytosis which are receptors overexpressed on prostate cancer cells...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
displacement of [superscript 125]I-BBN from the human PC-3 prostate cancer cell line. Labeling with [superscript nat]In and [superscript 111]In were successfully performed. The degree of in vitro internalization and efflux of [superscript 111]In...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re(PR3)2(tmf2en)]+ were prepared...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic substituents was investigated...
Investigation and modeling of carbon dioxide adsorption within porous materials
(University of Missouri--Columbia, 2023)
Mathematics has long been my special interest. With that in mind, if I make any operations which are unobvious to the reader, I deeply apologize. I often forget that, even within the STEM fields, not everyone enjoys spending ...
Energy transfer at gas-liquid interface : towards energetic materials
(University of Missouri--Columbia, 2007)
system, representing nitramine-type energetic materials. Having had a good potential description for the nitromethane molecule including all internal degrees of freedom, we generated simplified molecular systems based on the original nitromethane model...
Synthesis of mixed metal-organic pyrogallol[4]arene nanocapsules and their host-guest chemistry
(University of Missouri--Columbia, 2009)
. As a result, it is shown that the addition of different metal centers into this assembly results in the formation of a series of mixed metal MONCs with varied degrees of Ga composition and various shape change of the final nano-container. In addition...
Theranostic and matched pair radionuclides as radiopharmaceutical as for imaging and radiotherapy
(University of Missouri--Columbia, 2020)
]AsSR are underway. 4-6 Chapter 4 investigates the synthesis and evaluation of a monoamine monoamide dithiol (MAMA) ligand with an improved hydrophilicity for developing bifunctional chelators and their 186/188Re compounds. A series of NxS4-x tetradentate chelates...