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Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
and biological applications. As a two-dimensional material, molybdenum disulfide (MoS2) has drawn wide attention due to its fascinating properties and exciting application prospects. However, in order to access these properties, which lie within single- or few...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
[kappa][subscript 0]. The model was also combined with MONTEBURNS and ORIGEN to test the feasibility of Mo[superscript 99] production at MURR from fissioning LEU. Results from a 5-gram low-enriched uranium target show predictions of Mo[superscript 99] end...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
to increasing spectral resolution as excitation wavelength increases, multi-excitation datasets are notoriously difficult to align spectral features. In addition, the subtraction of the water band can be difficult when relying on an internal intensity standard...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic data (UV...
Comparison of hyperbranched and dendritic polymers with fluorescent reporter molecules
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hyperbranched polymers containing a core region are a relatively new class of polymers with many similarities to dendrimers, including their proposed ...
Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
elements of Mg, Mn, Fe, Cu, Zn and Mo levels in the plasma from the tobacco budworm, Heliothis virescens, following infection of the insect with a baculovirus (Helicoverpazea single nucleopolyhedrovirus (HzSNPV)) and bacteria (Micrococcus lysodeikticus...
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)
through numerous cellular internalization studies undoubtedly revealed that Res-PdNP-4 nanoparticles can be internalized into prostate cancer cells via laminin receptor-mediated endocytosis which are receptors overexpressed on prostate cancer cells...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
displacement of [superscript 125]I-BBN from the human PC-3 prostate cancer cell line. Labeling with [superscript nat]In and [superscript 111]In were successfully performed. The degree of in vitro internalization and efflux of [superscript 111]In...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re(PR3)2(tmf2en)]+ were prepared...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic substituents was investigated...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues...
Energy transfer at gas-liquid interface : towards energetic materials
(University of Missouri--Columbia, 2007)
system, representing nitramine-type energetic materials. Having had a good potential description for the nitromethane molecule including all internal degrees of freedom, we generated simplified molecular systems based on the original nitromethane model...
Synthesis of mixed metal-organic pyrogallol[4]arene nanocapsules and their host-guest chemistry
(University of Missouri--Columbia, 2009)
. As a result, it is shown that the addition of different metal centers into this assembly results in the formation of a series of mixed metal MONCs with varied degrees of Ga composition and various shape change of the final nano-container. In addition...
Characterizing and understanding self-assembling, nanocapsule host-guest systems
(University of Missouri--Columbia, 2010)
Supramolecular, self-assembled nanocapsules have been shown to be capable of entrapping fluorescent guests. Previous solid- and solution-state research, focusing on hydrogen-bonded C-alkylpyrogallol[4]arenes (PgC6)nanocapsules, ...
Crossed-beam chemical reaction dynamics probed with universal and state resolved ion imaging
(University of Missouri--Columbia, 2018)
The main goal of chemical reaction dynamics is to unravel the intimate motions of individual atoms during a chemical transformation. This information must generally be inferred from indirect macroscopic measurement. Very ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
. Chelate systems comprised of tertiary phosphines may serve as internal reducing agents, thus limiting the amount of ethanol and decreasing the temperatures required for labeling [superscript 105]RH. The chelate systems PS2, P2N2, and P2S2 have been...
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)
Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...