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Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
[kappa][subscript 0]. The model was also combined with MONTEBURNS and ORIGEN to test the feasibility of Mo[superscript 99] production at MURR from fissioning LEU. Results from a 5-gram low-enriched uranium target show predictions of Mo[superscript 99] end...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
to increasing spectral resolution as excitation wavelength increases, multi-excitation datasets are notoriously difficult to align spectral features. In addition, the subtraction of the water band can be difficult when relying on an internal intensity standard...
Comparison of hyperbranched and dendritic polymers with fluorescent reporter molecules
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hyperbranched polymers containing a core region are a relatively new class of polymers with many similarities to dendrimers, including their proposed ...
Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
elements of Mg, Mn, Fe, Cu, Zn and Mo levels in the plasma from the tobacco budworm, Heliothis virescens, following infection of the insect with a baculovirus (Helicoverpazea single nucleopolyhedrovirus (HzSNPV)) and bacteria (Micrococcus lysodeikticus...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
displacement of [superscript 125]I-BBN from the human PC-3 prostate cancer cell line. Labeling with [superscript nat]In and [superscript 111]In were successfully performed. The degree of in vitro internalization and efflux of [superscript 111]In...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues...
Energy transfer at gas-liquid interface : towards energetic materials
(University of Missouri--Columbia, 2007)
system, representing nitramine-type energetic materials. Having had a good potential description for the nitromethane molecule including all internal degrees of freedom, we generated simplified molecular systems based on the original nitromethane model...
Synthesis of mixed metal-organic pyrogallol[4]arene nanocapsules and their host-guest chemistry
(University of Missouri--Columbia, 2009)
. As a result, it is shown that the addition of different metal centers into this assembly results in the formation of a series of mixed metal MONCs with varied degrees of Ga composition and various shape change of the final nano-container. In addition...
Characterizing and understanding self-assembling, nanocapsule host-guest systems
(University of Missouri--Columbia, 2010)
Supramolecular, self-assembled nanocapsules have been shown to be capable of entrapping fluorescent guests. Previous solid- and solution-state research, focusing on hydrogen-bonded C-alkylpyrogallol[4]arenes (PgC6)nanocapsules, ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
. Chelate systems comprised of tertiary phosphines may serve as internal reducing agents, thus limiting the amount of ethanol and decreasing the temperatures required for labeling [superscript 105]RH. The chelate systems PS2, P2N2, and P2S2 have been...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Alkene-oxo and alkene-alkene coupling on Pt(II)
(University of Missouri--Columbia, 2005)
the norbornene reaction, which gave platinaoxetane [(COD)2Pt2(OC7H10)Cl]BF4 (4), the first metallaoxetane obtained from the direct reaction of an oxo complex and an alkene. A facile alkene-exchange reaction was observed between platinaoxetane 4 and norbornene...
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of ...
Toward polar 1,4-diphenylbutadiene materials
(University of Missouri--Columbia, 2004)
The fast response time of [pi]-electrons makes organic materials increasing interesting as highly anisotropic materials. We are especially interested in dipole parallel-aligned crystals because of the much higher chromophore ...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
radioiodinated 1h-7 showed that it had high specific binding to the sigma1 receptor in the mouse brain and thus it had great potential as SPECT agent for brain imaging. The modifications on the benzamide series of compounds by rigid dioxy rings showed similar...
From carbon to copper : studies of novel nanomaterials
(University of Missouri--Columbia, 2007)
Nanomaterials are materials on the order of 10-9 m that are currently being investigated for use in a wide range of applications in the growing field of nanotechnology. This dissertation documents the synthesis, characterization, and applications...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corannulene (C[subscript 20]H[subscript 10]), a polycyclic aromatic hydrocarbon (PAH) is a bowl shaped fullerene fragment. This work involves investigations into the chemistry...