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What are the current treatment and monitoring recommendations for hepatitis C virus (HCV)?
(Family Physicians Inquiries Network, 2001)
. Therapy with interferon and ribavirin (dual therapy) has been shown in randomized placebo-controlled trials to lead to sustained viral response in 30% to 50% of patients compared with 6% to 21% with PEG-interferon alpha-2b (Viraferson PEG) therapy only...
What is the best strategy for monitoring the lipid-lowering effects of medical therapy used for the primary prevention of coronary artery disease (CAD)?
(Family Physicians Inquiries Network, 2001)
There is good evidence that treatment for primary prevention of CAD decreases risk of major first coronary events and cardiovascular mortality, though all-cause mortality has not been shown to be reduced. There is no ...
What laboratory monitoring is appropriate to detect adverse drug reactions in patients on cholesterol-lowering agents?
(Family Physicians Inquiries Network, 2001)
Recommendations for measuring serum aminotransferase levels before initiating pharmacologic treatment for hypercholesterolemia, after 12 weeks of therapy, and periodically afterward are based on expert opinion. It is not ...
Is there any benefit to Papanicolaou (Pap) test screening in women who have had a hysterectomy for benign disease?
(Family Physicians Inquiries Network, 2001)
The primary motivation to screen asymptomatic women after a hysterectomy is to prevent morbidity and mortality from gynecologic cancer. However, primary vaginal cancer is rare, the vaginal Pap test is not particularly ...
What is the best way to diagnose menopause?
(Family Physicians Inquiries Network, 2005)
No single test for menopause is highly sensitive and specific. The best predictors that a woman will enter menopause within 4 years include age at least 50 years, amenorrhea for 3 to 11 months, and menstrual cycle irregularity within 12 months...
Stroke prevention: Age alone does not rule out warfarin
(Family Physicians Inquiries Network, 2007)
Warfarin is as safe as aspirin and more effective for stroke prevention in elders with atrial fibrillation. Stength of recommendation (SOR) A: Well-designed randomized controlled trial of elderly patients in the primary ...
Does stimulant therapy help adult ADHD?
(Family Physicians Inquiries Network, 2003)
Central nervous system stimulants improve symptoms of attention deficit-hyperactivity disorder (ADHD) in adults (strength of recommendation: B, based on an older, inconclusive systematic review, a lesser-quality systematic ...
How effective is gastric bypass for weight loss?
(Family Physicians Inquiries Network, 2004)
Gastric bypass results in weight loss of approximately 33% at 2 years and 25% at 8 years (strength of recommendation [SOR]: B, based on a cohort study). Gastric bypass is one type of bariatric surgery, which also includes ...
What are the risks and benefits of elective induction for uncomplicated term pregnancies?
(Family Physicians Inquiries Network, 2006)
Elective induction of labor for term, singleton, uncomplicated pregnancies appears safe for both the mother and infant (strength of recommendation [SOR]: B). The benefit of elective induction for nonmedical reasons is ...
Mizzou weekly, volume 23, number 11 (November 1, 2001)
(University of Missouri--Columbia. University Affairs. Publications and Alumni Communication., 2001)
What steps can reduce morbidity and mortality caused by hip fractures?
(Family Physicians Inquiries Network, 2007)
Surgery within 24 hours of hip fracture is a critical step in reducing complications, and may decrease mortality compared with conservative care (strength of recommendation [SOR]: B, cohort studies). Give patients heparin ...
For knee pain, how predictive is physical examination for meniscal injury?
(Family Physicians Inquiries Network, 2004)
No single clinical examination element, or combination of such elements, reliably detects meniscal injury. The McMurray test is best for ruling in meniscal pathology. Assuming a 9% prevalence of meniscal tears among all ...
What screening tests should you use to evaluate a man with low testosterone?
(Family Physicians Inquiries Network, 2008)
Obtain a repeat morning testosterone level, as well as levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin to help understand the cause of low testosterone when there is a lack of adequate ...
Which anticoagulant is safest for frail elderly patients with nonvalvular A-fib?
(Family Physicians Inquiries Network, 2022-11)
Consider apixaban, which demonstrated a lower adverse event (AE) rate than warfarin regardless of frailty status, for anticoagulation treatment of older patients with nonvalvular atrial fibrillation (AF); by comparison, ...
Are DMARDs effective for rheumatologic diseases besides rheumatoid arthritis?
(Family Physicians Inquiries Network, 2007)
It's unclear whether disease-modifying antirheumatic agents (DMARDs) as first-line therapy in nonrheumatoid rheumatologic diseases are effective because the question has not been studied. As second-line therapy, the use ...
How can you best diagnose idiopathic normal pressure hydrocephalus?
(Family Physicians Inquiries Network, 2007)
Diagnose idiopathic normal pressure hydrocephalus (INPH) by clinical history, brain imaging, physical findings, and physiological criteria. The clinical examination must show the characteristic gait disturbance and either ...
Do antioxidants (vitamins C, E) improve outcomes in patients with coronary artery disease?
(Family Physicians Inquiries Network, 2002)
Antioxidant supplements of vitamins E and C do not reduce cardiovascular death in people with coronary artery disease. Vitamin E supplementation, in a variety of doses, does not decrease the incidence of cardiovascular or ...
Consider this option for heavy menstrual bleeding
(Family Physicians Inquiries Network, 2011)
Offer tranexamic acid to patients with heavy menstrual bleeding. The extended-release formulation is effective and well tolerated. Stength of recommendation: A: Based on 1 good-quality randomized controlled trial (RCT).
Mizzou weekly, volume 23, number 12 (November 8, 2001)
(University of Missouri--Columbia. University Affairs. Publications and Alumni Communication., 2001)
Debt types and burdens by family structures
(2020)
Purpose: The purpose of this study is to examine family structure differences in debt types and burdens of American families. Design/methodology/approach: Data are obtained from the 2016 Survey of Consumer Finances. Eight types of family structures...