Search
Now showing items 1-8 of 8
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
-of-the-eye tissues (retina-choroid) following conjunctival-scleral pathway. In the lipoidal posterior ocular tissues, these nano-constructs may release the cargo into Bruch’s membrane/retina-choroid generating high drug levels....
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)
in sanctuary sites such as brain resulting in persistent viral replication and may lead to viral resistance. Sub-therapeutic concentration of PIs in brain leads to drug resistance and HIV associated dementia. One of the major factors which limit central nervous...
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)
The main objective of this project is to develop prodrug strategies to circumvent efflux
pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs),
thereby enhancing oral and brain absorption ...
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...
Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
(2015-08-11)
The primary objective of this project is to develop drug-loaded polymeric nanoparticles
suspended in a biocompatible gel for topical delivery of therapeutic agents commonly
employed in the treatment of ocular viral/bacterial ...