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Performance standards for walk-in coolers and freezers in the United States as a function of local weather conditions
(University of Missouri--Kansas City, 2011-05-26)
Walk-in coolers and freezers are medium (~35º F) and low (~-10º F to -20º F)
temperature commercial food preservation equipment, with high market demand. There is
considerable potential for energy savings through ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
-of-the-eye tissues (retina-choroid) following conjunctival-scleral pathway. In the lipoidal posterior ocular tissues, these nano-constructs may release the cargo into Bruch’s membrane/retina-choroid generating high drug levels....
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Ab Initio Study of Amorphous Zeolitic Imidazolate Framework (A-ZIF) and Pyrophosphate crystals
(2020)
Zeolitic imidazolate frameworks (ZIFs) are a rapidly emerging class of versatile porous material with many potential applications. Here, we report the construction of an amorphous ZIF (a-ZIF) model from a near-perfect ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
(DNA)/nucleosides to assess the activity of Ten-Eleven Translocation 2 (TET2) enzyme. Methylation of one of the DNA bases, cytosine at the C-5 position (5-methylcytosine, 5mC) plays a crucial role in epigenetic transcriptional regulation. TET-family...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)
HIV/AIDS had caused more than 25 million deaths since it was first recognized.
Women are more susceptible to HIV infection in comparison with men due to human
physiology, social, economic disadvantages. To protect women ...
Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications
(2013)
Valvular complications and atherosclerosis contribute to the majority of the
cardiovascular disease related deaths worldwide. In this thesis project the role of
normative tissue mineral concentrations in native and ...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
transporters is generally considered to be restricted to cell surface level. However, cellular compartments may also be a potential site for these transporters. The functional localization of both efflux (MDR1) and influx (PepT-1) transporters...
Hydrolysis and aqueous corrosion of silicate and aluminosilicate glasses via ab initio molecular dynamics simulation
(2021)
Hydrolysis and aqueous corrosion of glass is a complex and puzzling phenomenon. Although many endeavors have been made to investigate corrosion in glass, it is still an open question with many unanswered fundamental issues. ...
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)
The research presented in this dissertation was aimed at understanding several structural and biochemical features underlying the bacterial cell wall biosynthetic process using statistical, biochemical and analytical tools. ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)
This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development ...
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)
in sanctuary sites such as brain resulting in persistent viral replication and may lead to viral resistance. Sub-therapeutic concentration of PIs in brain leads to drug resistance and HIV associated dementia. One of the major factors which limit central nervous...
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to present various approaches for treatment cancer,
which is the leading cause of death worldwide. Compared to other disease, cancer has many
unique biological characteristics that ...
Organoisocyanates: the conformational stability determination by infrared, raman and microwave spectroscopy and ab initio calculation
(University of Missouri-Kansas City, 2012)
Conformational stability studies have been carried out for several quasilinear organoisocyanates and organoisothiocyanates. The infrared and Raman spectra in the gaseous, liquid and solid phases have been recorded as well ...
Practical Applications of Infrared, Raman and Nuclear Magnetic Resonance Spectroscopic Techniques for Qualitative, Quantitative and Structural Analysis of Pharmaceutical Drugs, Cementitious Material and Organic Molecules Containing Phosphorous
(University of Missouri--Kansas City, 2016)
The study of the interaction between matter and electromagnetic radiation which procreated the wide branch named as Spectroscopy has gained tremendous attention since the last century. Atoms and molecules respond to ...
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to design and optimize a nanoformulations
(nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for
HIV prevention in women.
In chapters 1 and ...
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)
≤ 0.5) like imipenem and biapenem were identified. Moreover, many agents showed weak synergy (0.5 < FICmin ≤ 0.75), such as nafcillin, doripenem, meropenem, and moxalactam....