[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] From the onset the goal of this thesis work was to determine the role that a novel class of growth factors, i.e. hematopoietic cytokines, was playing ...

Cystic fibrosis transmembrane conductance regulator (CFTR) is the only ATP binding cassette (ABC) protein that functions as an ion channel. The clinical importance of CFTR lies in the fact that its malfunction causes the ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The prevalence of obesity and diabetes is rising dramatically worldwide. Increased adiposity is associated with elevated cardiovascular risk factors, ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Despite avid attempts, non-surgical methods such as diet aids, behavioral modification and exercise are typically unsuccessful in achieving long term ...

The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ...

physiological conditions, we examined the effects of fat from db/db mice on vascular function. The data showed that in db/db mice, both of these 'vaso-protective' effects were lost at early (6-10 weeks) and later (18-22 weeks) stages of T2DM in the presence...

. While it is often presumed that all non-specialized endothelial cells are the same, and thus will have the same response to various pharmacological agents, disease states, and stimuli, this may not be true. Our goal is to understand if endothelial cell...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Rho GTPases regulate a diverse spectrum of cellular functions involved in vascular morphogenesis. Here, we show that Cdc42 and Rac1 play a key role ...

the progression of tissue injury, it also initiates a complex series of microvascular inflammatory changes which paradoxically induce additional cellular damage beyond ischemia alone. Pharmacological preconditioning is a powerful protective intervention against...

Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ...

Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this context, we administered ethanol intraperitoneally to rats, to mimic binge drinking in humans. A dose response ...

During vascular morphogenic events, mural cells are recruited to developing endothelial tubes to aid in stabilization and maturation of the new vessels. There are two known types of mural cells, pericytes and vascular ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The arterial baroreceptors are responsible for mediating rapid reflex adjustments to acute cardiovascular stressors via modulating autonomic nervous ...

Atherosclerosis is a progressive inflammatory disease that is present in large vessels in the body. We hypothesized that either adiponectin treatment or soluble Receptor for Advanced Glycation Products (sRAGE) treatment ...

Disseminating single cells and multicellular aggregates (MCAs) and experience compressive forces exerted upon them by ascites fluid and are exposed to lysophosphatidic acid, aberrantly adhesive mesothelium and a collagen-rich ...

on chemical changes in the brain and cord (except in regard to phosphorus and water) possibly on account of the difficulty of obtaining material and, more especially, the lack of sufficiently accurate methods. The publication of a "Method for Quantitative...

Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ...