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Cyclotron produced nuclides for PET imaging and radiotracer studies
(University of Missouri--Columbia, 2015)
at the Missouri University Research Reactor, MURR. The copper-64 was also separated, purified and labeled successfully by researcher at MURR....
Radionuclide production for radioisotope micro-power source technologies
(University of Missouri--Columbia, 2008)
at the University of Missouri Research Reactor (MURR) for ₃₅S and ₁₄₇Pm....
Fission product diffusion in ig-110 graphite
(University of Missouri--Columbia, 2022)
demonstrated ability to migrate through all core structures and deposit onto cooling system components. This poses a danger to reactor workers and, if the closed coolant circuit were to be compromised, the public. With that in mind, it is essential to fully...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
A novel approach to parametric instrumental neutron activation analysis at MURR has been established. In particular, a detailed MCNP5 steady-state model of the MURR core was developed. The model, which was based on the ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of the reactor core at MURR...
Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent
(University of Missouri--Columbia, 2022)
chemical characteristics of Re and Tc in theory may allow 186Re-based radiopharmaceuticals to be developed as therapeutic analogues to their 99mTc counterparts. In this research, two methods were evaluated for the production and separation of HSA 186Re...
Isotope harvesting from the beam dump cooling loop at the facility for rare isotope beams (FRIB)
(University of Missouri--Columbia, 2018)
for research in biomedicine, energy, environmental studies, and materials science, and yet they are destined for disposal. One option for retrieval of these rare isotopes is harvesting from the spent mixed-bed resin in a batch collection mode. Alternatively...
Oxidative molecular layer deposition of redox-active thin-film polymers
(University of Missouri--Columbia, 2022)
Thin film materials research for a more sustainable future is growing rapidly and new techniques for depositing these films are beginning to surface. One such technique is highlight in this body of work using gaseous precursors to grow bottom...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
quantification of 14 different PFAS. Method LOQs for all analytes are below EPA advisory limit of 70 ppt. The calibration curves range from 0.5-140 ng/ml. The method was then applied to evaluate the effectiveness of a supercritical water oxidation (SCWO) reactor...
Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals
(University of Missouri--Columbia, 2007)
Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
(III) are kinetically inert with respect to ligand exchange. [superscript 105]RH is produced by neutron irradiation of an enriched 104Ru target at the University of Missouri Research Reactor (MURR) in high specific activity, by separation from the target material...
Selection of small pretargeting peptides with affinity for radiochelates and separation and purification of radiolanthanides
(University of Missouri--Columbia, 2014)
. The reactor produced radiolanthanides, such as ???�??�?Lu, ???�???Tb and ???�??�?Ho, have nuclear properties useful for diagnos...
Theranostic and matched pair radionuclides as radiopharmaceutical as for imaging and radiotherapy
(University of Missouri--Columbia, 2020)
to the renal system. 7 The ongoing research presented in chapter 4 focuses on synthesis and evaluation of a 222-MAMA chelate with an improved hydrophilicity followed by radiolabeling with 99mTc and 186Re. Conjugation of 222-MAMA-(N-6-Ahx-OEt) to RM2 peptide...
Novel syntheses and behavior of precious metal nanoparticles
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] In this work, I report the detailed syntheses of both gold-doped iron oxide (Au@Fe2O3) and silver nanocrystals (AgNCs). The Au@Fe2O3 was produced through ultrasonic...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over the past 50 years...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)
Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an attempt to develop non...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues...
Measurement of radionuclides in biological tissues from occupationally exposed individuals
(University of Missouri--Columbia, 2022)
the concentration of radionuclides in brain tissues may allow researchers to access the neurological outcomes associated with chronic internal exposure to radiation. ICP-MS analysis allows easy and accurate analysis of multiple elements. This work developed...