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Investigating increased shear stress and physical activity as strategies to improve vascular insulin sensitivity
(University of Missouri--Columbia, 2020)
by participation in an eight-week exercise program, in the form of increased walking, was interrogated. Despite an improvement in popliteal artery flow-mediated dilation, microvascular insulin resistance was not improved in T2D following an eight-week walking...
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes
(University of Missouri--Columbia, 2022)
/db mesenteric arteries is abrogated by inhibition of nitric oxide (NO) synthase; and 3) stimulation of smooth muscle cells or db/db mesenteric arteries with a NO mimetic reduces stiffness. Last, in vivo treatment of db/db mice with adropin for four weeks reduced...
The brown adipose tissue phenoype : metabolic implications
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models; ...
The role of heat shock protein 72 in endothelial insulin resistance in type 2 diabetes: using passive heat therapy to improve endothelial insulin responsiveness
(University of Missouri--Columbia, 2022)
Impaired endothelial insulin signaling and consequent blunting of insulin-induced vasodilation is a feature of type 2 diabetes (T2D) and contributes to vascular disease and glycemic dysregulation. However, the molecular ...