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Role of adropin in arterial stiffening associated with obesity and type 2 diabetes
(University of Missouri--Columbia, 2022)
/db mesenteric arteries is abrogated by inhibition of nitric oxide (NO) synthase; and 3) stimulation of smooth muscle cells or db/db mesenteric arteries with a NO mimetic reduces stiffness. Last, in vivo treatment of db/db mice with adropin for four weeks reduced...
The role of heat shock protein 72 in endothelial insulin resistance in type 2 diabetes: using passive heat therapy to improve endothelial insulin responsiveness
(University of Missouri--Columbia, 2022)
Impaired endothelial insulin signaling and consequent blunting of insulin-induced vasodilation is a feature of type 2 diabetes (T2D) and contributes to vascular disease and glycemic dysregulation. However, the molecular ...