Overall aim of this research project is to develop folic acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that ...

Herpes simplex virus infections (HSV) in the eye are one of the leading causes of blindness across the world. Current available treatment options to treat HSV infections are solutions of trifluorothymidine (TFT), idoxuridine ...

Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to facilitate ACV cellular transport. All the prodrugs were screened ...

HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the ...

Pentablock copolymers comprised of multi-polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for fabrication of nanoparticles and thermosensitive hydrogel ...

Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ...

Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of the most common infectious diseases causing corneal blindness in the United States. In this study, polymeric nanoparticles ...

Drug abuse is an escalating problem prevalent in both large metropolitan and rural places and is a major cause of mortality and morbidity all over the world. Drugs of abuse such as morphine and nicotine are consumed by ...

Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ...

Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic intracellular drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and ...

Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins ...

Recurrent brain tumors are one of the most lethal forms of solid tumors with poor prognosis. Molecularly targeted therapy, inhibiting the tyrosine kinase domain of epidermal growth factor receptor (EGFR), platelet derived ...

Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ...

This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ...

Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ...

PART I: DIPEPTIDE PRODRUG APPROACH TO IMPROVE INTESTINAL ABSORPTION OF LOPINAVIR Lopinavir (LPV), a highly potent second-generation HIV-1 protease inhibitor, is currently indicated in HIV-1 infection. However, poor ...

The main objective of this project is to develop prodrug strategies to circumvent efflux pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs), thereby enhancing oral and brain absorption ...

Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...

Pentablock (PB) copolymers have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as ...

Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized. Low molecular weight diblock co-polymers, ...