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Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)
The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly ...
Uncovering the genetic basis of seed amino acid composition in arabidopsis using a multi-omics integrative approach
(University of Missouri--Columbia, 2021)
to create a seed with a more balanced amino acid profile. However, upon perturbations to the proteome, mutant seeds have demonstrated a rebalancing phenomenon where even large alterations to the amino acid composition activate a compensation mechanism...
Uncovering the genetic architecture and metabolic basis of amino acid composition in maize kernels using multi-omics integration
(University of Missouri--Columbia, 2020)
are met. Many attempts to increase the EAA has demonstrated only limited success since seed can rebalance their amino acids composition even when major changes are introduced in their proteome. One possible approach to solve this applied problem is by seed...
Flipping the switch : regulation of proliferation and differentiation in adult muscle stem cells
(University of Missouri--Columbia, 2011)
Adult muscle stem cells or satellite cells are the committed somatic stem cells responsible for maintenance and regeneration of adult skeletal muscle tissue. Skeletal muscle is capable of multiple rounds of complete ...
From unique killers to a jumbo genome - isolation and characterization of phages that infect the plant pathogen, Agrobacterium tumefaciens
(University of Missouri--Columbia, 2019)
Bacteriophages and their lytic peptides can protect plants from phytopathogens such as Agrobacterium tumefaciens. To better understand mechanisms of phagemediated host killing, we isolated and characterized five lytic ...
Elucidation of the genetic control of carbohydrate partitioning in Zea mays
(University of Missouri--Columbia, 2019)
. Appendix C analyzes the expression levels and potential roles of SWEET and TST transporters in sweet and grain sorghum. I was responsible for the expression analysis of the SWEET genes discussed in this publication....
Generating temperature sensitive inteins for studying gene functions
(University of Missouri--Columbia, 2008)
Reversible and easy to use, temperature-sensitive (TS) mutations, are powerful tools to study the functions of all genes, including essential and pleiotropic ones. However, the rarity of TS alleles and the difficulty of ...
Investigations into the cause of pollen abortion in maize CMS-C
(University of Missouri--Columbia, 2009)
Cytoplasmic male sterility type C (CMS-C) is atypical compared to other CMS types as no novel chimeric transcript or protein has been found correlating with the phenotype. However, a tassel-specific decrease for both ATP6 ...
The molecular underpinnings of neuronal cell identity in the stomatogastric ganglion of cancer borealis
(University of Missouri--Columbia, 2019)
Throughout the life of an organism, the nervous system must be able to balance changing in response to environmental stimuli with the need to produce reliable, repeatable activity patterns to create stereotyped behaviors. ...
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase ...
Tumor-initiating cells in malignant brain tumors
(University of Missouri--Columbia, 2009)
Stem cells have the unique ability to differentiate into the many specialized cells of the body. During adulthood, stem cells remain in the organism and maintain the ability to repair and replenish injured or dead cells ...
Insights into phototropic signaling : a study of the unusual attributes of a hyper-phototropic mutant
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Many questions persist about the nature of and components associated with the initial signaling events that follow light perception for phototropism. ...
Genetic and hormonal regulation of meristem initiation and maintenance pathways during maize vegetative and reproductive development
(University of Missouri--Columbia, 2021)
Plant development is driven by pools of undifferentiated stem cells called meristems. Meristems have two functions, to divide producing cells that will replenish the stem-cell niche, and cells that will differentiate into ...
Regulation of plant development in Arabidopsis
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The development of a complex organism, such as a plant, requires the function of multiple pathways that regulate various aspects of the developmental ...
Dissecting the genetic basis of carbohydrate partitioning in maize and sugarcane
(University of Missouri--Columbia, 2022)
Carbohydrate partitioning, the process by which carbohydrates synthesized in the photosynthetic source tissues (mature leaves) are mobilized to non-photosynthetic (sink) tissues, such as roots, seeds, and developing organs ...
Characterizing a model of early human placenta
(University of Missouri--Columbia, 2020)
In the few weeks following fertilization of a human ovum, there is little known about the events of early human development. What we do know we've learned from a few collections of fixed sections of implantation sites ...
The blue light responses and lifetime fitness of a hyper-phototropic mutant in Arabidopsis thaliana and Zea mays
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Optimal plant growth and development hinges on the plant's ability to absorb sunlight. Because plants are sessile, they have evolved a variety of ...
Role of non-hypophototropic hypocotyl[3] (NPH[3]) in regulation of phototropism in Arabidopsis
(University of Missouri--Columbia, 2008)
phototropic responsiveness.--From public.pdf...
Mechanisms of polar growth in the alphaproteobacterial order rhizobiales
(University of Missouri--Columbia, 2019)
All bacteria elongate and divide to faithfully reproduce their cell shape. Understanding the mechanisms that drive bacterial morphology requires an intimate knowledge of how the cell wall is synthesized. During cell ...
Phylogenomics of orchids and their mycorrhizal fungi : trees, diversity, and the pursuit of symbiosis
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Phylogenetic trees show us how organisms are related and provide frameworks for studying and testing evolutionary hypotheses. To better understand the ...