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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
(2014-08-28)
Tissues such as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression ...
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and
Drug Administration in the United States for the treatment of HIV infection due to its
potent anti-HIV activity. However, some unfavorable ...
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic
intracellular drug concentration, is one of the predominant factors limiting effective cancer
chemotherapy. Several possible mechanisms and ...
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)
Prostate cancer is the most common male malignancy and remains the second-leading
cause of death due to cancer in American men. While surgery and radiation are effective in
prostate cancer therapy at early stages, the ...
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop various systems to deliver small
interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and
liver fibrosis. siRNAs targeting vascular endothelial ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)
Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. ...
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)
There are two major research objectives in this dissertation. Our laboratory
recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding
protein 2 (PCBP2) gene. It is hypothesized that silencing ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
The Investigation of Configurationally Stable Longitudinally Twisted Acenes and the Development of a Silorane-Based Biomaterial for Use as an Antimicrobial Delivery Device
(2019)
Longitudinally twisted acenes (LTAs) adopt a helical twist in order to alleviate steric congestion caused by bulky substituents along the acene backbone and are inherently chiral. As is observed in helicenes, this helical ...
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)
This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)
The objective of this project was to develop advanced nanocarriers such as
nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced
graphene oxide (Man-rGO) was developed as a targeted ...
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)
HIV/AIDS had caused more than 25 million deaths since it was first recognized.
Women are more susceptible to HIV infection in comparison with men due to human
physiology, social, economic disadvantages. To protect women ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...
Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics
(2021)
In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
(2019)
In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ...