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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
(University of Missouri--Kansas City, 2011-01-20)
into possible reasons for inconsistencies reported from various laboratories....
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
Biogeochemistry and inorganic geochemistry as indicators of the paleoenvironment and paleohydrology of the Al-Azraq Basin, Jordan
(2013)
This study investigates the biogeochemical and inorganic geochemical
indicators for past environments and paleohydrology of a high resolution sediment record
from the Al-Azraq Basin, Jordan. The second largest basin in ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
approaches to tribenzopentaphene (TBP) derivatives are reported and their optical, electrochemical, self-assembly, and photovoltaic properties are studied. It is shown that TBP derivatives are good electron donors which, when coated on pre...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins ...
Synthesis and analysis of siloranes for use as a biomaterial and extended twisted molecular ribbons
(2013)
The development of complex organic molecules with industrial potential requires
meticulous synthetic methodologies coupled with detailed investigations surrounding their
physical properties. This dissertation encompasses ...
Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers
(2021)
The underlying theme at the forefront of synthetic organic chemistry has always been about compounding simple precursors into more complex molecular targets. However, this strenuous process often involves the generation ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to present various approaches for treatment cancer,
which is the leading cause of death worldwide. Compared to other disease, cancer has many
unique biological characteristics that ...
Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
(2014)
Due to the high tendency to form π-stacked ordered phases, polycyclic aromatic hydrocarbons (PAHs) are attractive building blocks for the assembly of conjugated systems for electronic applications. The body of this ...
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
(2014-08-28)
Tissues such as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression ...
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
(University of Missouri -- Kansas City, 2011-05-03)
Arynes and heteroarynes are very important and useful reactive intermediates with many applications in organic synthesis, including natural products total synthesis. Although benzyne, the parent and most famous aryne, has ...
Performance standards for walk-in coolers and freezers in the United States as a function of local weather conditions
(University of Missouri--Kansas City, 2011-05-26)
Walk-in coolers and freezers are medium (~35º F) and low (~-10º F to -20º F)
temperature commercial food preservation equipment, with high market demand. There is
considerable potential for energy savings through ...
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)
Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of
the most common infectious diseases causing corneal blindness in the United States. In this
study, polymeric nanoparticles ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic
intracellular drug concentration, is one of the predominant factors limiting effective cancer
chemotherapy. Several possible mechanisms and ...
Interactions between drugs of abuse and HIV protease inhibitors
(2014-07-09)
Drug abuse is an escalating problem prevalent in both large metropolitan and rural
places and is a major cause of mortality and morbidity all over the world. Drugs of abuse
such as morphine and nicotine are consumed by ...
Raman, Infrared and Microwave Spectra, Conformational Stability, R₀ Structural Parameters and Vibrational Assignments of Some Organoamines, Organophosphines, Alcohols And Substituted Four And Five Membered Rings
(2014)
constants reported from microwave studies combined with the structural parameters predicted from the MP2(full)/6-311+G(d,p) calcualtions, adjusted r0 strutral paramerters have been obtained for the most stable conformer(s) of the different molecules studied....
Conformational stability of some silanes and amines from temperature dependent Infrared spectra of rare as solutions, r₀ structural parameters, ab initio calculations, and vibrational assignments
(University of Missouri--Kansas City, 2012-06-12)
rotation are also reported for some of the silane molecules. Potential functions governing conformational interchange were also determined, based on torsional transitions frequencies, conformational enthalpy differences and dihedral angles...