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Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
decreased Glutamate AMPA Receptor 1 (GluA1) protein levels, and neurogenesis. Our genetic model for high physical activity on the other hand had enhanced performance in cognitive behavioral testing, increased hippocampal volumes, and increased markers...
The role of Cdc42 Rho GTPase in the cystic fibrosis intestinal epithelial barrier
(University of Missouri--Columbia, 2022)
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. People with CF and CF mouse models experience increased intestinal permeability, but the molecular mechanisms ...